|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1997-6-17
|
|
pubmed:abstractText |
In the present study, the effects of gestation on various enzymes implicated in corticosteroid synthesis were evaluated in adrenal zona glomerulosa and zona fasciculata-reticularis of the Sprague-Dawley rat. The activity and expression of cholesterol side-chain cleavage cytochrome P450, 11beta-hydroxylase cytochrome P450, and aldosterone synthase cytochrome P450 (P450aldo) were analyzed. Plasma aldosterone levels were increased significantly at 22 days gestation (n = 10) and fell below the nonpregnant levels at 18-36 h postpartum (n = 11). The activity and expression of 11beta-hydroxylase cytochrome P450 and cholesterol side-chain cleavage cytochrome P450 were not modified by gestation. P450aldo activity increased at 14 days gestation (n = 4) and returned to the prepregnancy level at 2 weeks postpartum (n = 5). As shown by Northern blot analysis (n = 3), P450aldo messenger RNA increased significantly at 22 days gestation and decreased 18-36 h postpartum. We clearly demonstrated that elevated plasma aldosterone levels during pregnancy are associated with augmented activity and messenger RNA levels of P450aldo in the zona glomerulosa.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0013-7227
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
138
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2354-8
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9165022-Adrenal Cortex,
pubmed-meshheading:9165022-Aldosterone,
pubmed-meshheading:9165022-Aldosterone Synthase,
pubmed-meshheading:9165022-Animals,
pubmed-meshheading:9165022-Cholesterol Side-Chain Cleavage Enzyme,
pubmed-meshheading:9165022-Corticosterone,
pubmed-meshheading:9165022-Female,
pubmed-meshheading:9165022-Gestational Age,
pubmed-meshheading:9165022-Postpartum Period,
pubmed-meshheading:9165022-Pregnancy,
pubmed-meshheading:9165022-Pregnancy, Animal,
pubmed-meshheading:9165022-RNA, Messenger,
pubmed-meshheading:9165022-Rats,
pubmed-meshheading:9165022-Rats, Sprague-Dawley,
pubmed-meshheading:9165022-Steroid 11-beta-Hydroxylase,
pubmed-meshheading:9165022-Time Factors,
pubmed-meshheading:9165022-Transcription, Genetic,
pubmed-meshheading:9165022-Zona Fasciculata,
pubmed-meshheading:9165022-Zona Glomerulosa,
pubmed-meshheading:9165022-Zona Reticularis
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Effects of gestation on enzymes controlling aldosterone synthesis in the rat adrenal.
|
|
pubmed:affiliation |
Research Center, Sainte-Justine's Hospital, University of Montreal, Quebec, Canada. brochum@ere.umontreal.ca
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
