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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1997-5-29
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pubmed:abstractText |
The aim was to evaluate Leu-M1 immunoreactivity as a prognostic factor in phaeochromocytoma. Anti-Leu-M1 monoclonal antibodies were used to determine the Leu-M1 immunoreactivity in 17 histologically confirmed phaeochromocytomas from 15 patients, using an avidin-biotin technique. Ten patients had a sporadic phaeochromocytoma, and five had multiple endocrine neoplasia type 2A (MEN 2A). Malignancy was diagnosed in three patients by the presence of metastases. Leu-M1 immunoreactivity was shown in 12 (70.5%) phaeochromocytomas. Three patterns of arrangement were observed: isolated (scattered positive cells) (n = 3); focal (aggregates of positive cells) (n = 5), and diffuse patterns (dispersed positive cells) (n = 4). Two cases of malignant phaeochromocytoma were positive (one focal and one isolated pattern). All cases of MEN 2A showed immunoreactivity, although no characteristic pattern was prevalent. A diffuse pattern was observed in all phaeochromocytomas longer than 7 cm. In conclusion, Leu-M1 expression is frequent in phaeochromocytoma. However, Leu-M1 immunoreactivity seems to be useless in predicting malignant behaviour and to be influenced mainly by tumour size.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9155703-1571898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9155703-1640712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9155703-2807152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9155703-3085523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9155703-3116758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9155703-3887932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9155703-8076587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9155703-8105382
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-9746
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
168-70
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9155703-Adrenal Gland Neoplasms,
pubmed-meshheading:9155703-Adult,
pubmed-meshheading:9155703-Aged,
pubmed-meshheading:9155703-Antigens, CD15,
pubmed-meshheading:9155703-Female,
pubmed-meshheading:9155703-Humans,
pubmed-meshheading:9155703-Immunohistochemistry,
pubmed-meshheading:9155703-Male,
pubmed-meshheading:9155703-Middle Aged,
pubmed-meshheading:9155703-Multiple Endocrine Neoplasia Type 2a,
pubmed-meshheading:9155703-Pheochromocytoma,
pubmed-meshheading:9155703-Prognosis
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pubmed:year |
1997
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pubmed:articleTitle |
Leu-M1 immunoreactivity and phaeochromocytoma.
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pubmed:affiliation |
Department of Endocrinology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
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pubmed:publicationType |
Journal Article
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