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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-6-6
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pubmed:abstractText |
The transcriptional corepressors SMRT and N-CoR function as silencing mediators for retinoid and thyroid hormone receptors. Here we show that SMRT and N-CoR directly interact with mSin3A, a corepressor for the Mad-Max heterodimer and a homolog of the yeast global-transcriptional repressor Sin3p. In addition, we demonstrate that the recently characterized histone deacetylase 1 (HDAC1) interacts with Sin3A and SMRT to form a multisubunit repressor complex. Consistent with this model, we find that HDAC inhibitors synergize with retinoic acid to stimulate hormone-responsive genes and differentiation of myeloid leukemia (HL-60) cells. This work establishes a convergence of repression pathways for bHLH-Zip proteins and nuclear receptors and suggests this type of regulation may be more widely conserved than previously suspected.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/NCOR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Co-Repressor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SIN3A transcription factor,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/trichostatin A
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
373-80
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9150137-Antineoplastic Agents,
pubmed-meshheading:9150137-Cell Differentiation,
pubmed-meshheading:9150137-DNA-Binding Proteins,
pubmed-meshheading:9150137-Drug Synergism,
pubmed-meshheading:9150137-Enzyme Inhibitors,
pubmed-meshheading:9150137-Escherichia coli,
pubmed-meshheading:9150137-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:9150137-HL-60 Cells,
pubmed-meshheading:9150137-Histone Deacetylase Inhibitors,
pubmed-meshheading:9150137-Histone Deacetylases,
pubmed-meshheading:9150137-Humans,
pubmed-meshheading:9150137-Hydroxamic Acids,
pubmed-meshheading:9150137-Multienzyme Complexes,
pubmed-meshheading:9150137-Nuclear Receptor Co-Repressor 2,
pubmed-meshheading:9150137-Protein Structure, Tertiary,
pubmed-meshheading:9150137-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:9150137-Repressor Proteins,
pubmed-meshheading:9150137-Transcription Factors,
pubmed-meshheading:9150137-Tretinoin
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pubmed:year |
1997
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pubmed:articleTitle |
Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase.
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pubmed:affiliation |
The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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