| pubmed-article:9149166 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9149166 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9149166 | lifeskim:mentions | umls-concept:C0038411 | lld:lifeskim |
| pubmed-article:9149166 | lifeskim:mentions | umls-concept:C0040421 | lld:lifeskim |
| pubmed-article:9149166 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:9149166 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9149166 | pubmed:dateCreated | 1997-5-29 | lld:pubmed |
| pubmed-article:9149166 | pubmed:abstractText | We investigated cellular immunity against Streptococcus pyogenes in human tonsils by measuring antigen-specific immunoglobulin-secreting cells and the production of cytokines from CD4+ T cells in response to M proteins. The incidence of S pyogenes in tonsils was significantly higher in patients with recurrent tonsillitis (RT) than in patients with tonsillar hypertrophy (TH). M protein-specific immunoglobulin A (IgA) and immunoglobulin G spot-forming cells were increased in patients with RT compared with patients with TH. In RT the number of M protein-specific IgA spot-forming cells was significantly greater in the S pyogenes-negative subjects than in the S pyogenes-positive subjects. Proliferation of CD4+ T cells and production of interferon-gamma (IFN-gamma) and interleukins -2, -4, -5, and -6 (IL-2, IL-4, IL-5, and IL-6) from those T cells were observed in response to M protein. The concentrations of IFN-gamma and IL-4 were higher in RT than in TH. These findings suggest that S pyogenes is associated with the pathogenesis of RT and that immune responses against M protein may play an important role in preventing the colonization of this bacteria in tonsils. | lld:pubmed |
| pubmed-article:9149166 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9149166 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9149166 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9149166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9149166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9149166 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9149166 | pubmed:month | May | lld:pubmed |
| pubmed-article:9149166 | pubmed:issn | 0023-852X | lld:pubmed |
| pubmed-article:9149166 | pubmed:author | pubmed-author:MogiGG | lld:pubmed |
| pubmed-article:9149166 | pubmed:author | pubmed-author:KuronoYY | lld:pubmed |
| pubmed-article:9149166 | pubmed:author | pubmed-author:KerakawauchiH... | lld:pubmed |
| pubmed-article:9149166 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9149166 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:9149166 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9149166 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9149166 | pubmed:pagination | 634-9 | lld:pubmed |
| pubmed-article:9149166 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9149166 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9149166 | pubmed:articleTitle | Immune responses against Streptococcus pyogenes in human palatine tonsils. | lld:pubmed |
| pubmed-article:9149166 | pubmed:affiliation | Department of Otolaryngology, Oita Medical University, Hasama-machi, Japan. | lld:pubmed |
| pubmed-article:9149166 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9149166 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9149166 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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