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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-5-29
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pubmed:abstractText |
We investigated cellular immunity against Streptococcus pyogenes in human tonsils by measuring antigen-specific immunoglobulin-secreting cells and the production of cytokines from CD4+ T cells in response to M proteins. The incidence of S pyogenes in tonsils was significantly higher in patients with recurrent tonsillitis (RT) than in patients with tonsillar hypertrophy (TH). M protein-specific immunoglobulin A (IgA) and immunoglobulin G spot-forming cells were increased in patients with RT compared with patients with TH. In RT the number of M protein-specific IgA spot-forming cells was significantly greater in the S pyogenes-negative subjects than in the S pyogenes-positive subjects. Proliferation of CD4+ T cells and production of interferon-gamma (IFN-gamma) and interleukins -2, -4, -5, and -6 (IL-2, IL-4, IL-5, and IL-6) from those T cells were observed in response to M protein. The concentrations of IFN-gamma and IL-4 were higher in RT than in TH. These findings suggest that S pyogenes is associated with the pathogenesis of RT and that immune responses against M protein may play an important role in preventing the colonization of this bacteria in tonsils.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Outer Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloma Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/multiple myeloma M-proteins,
http://linkedlifedata.com/resource/pubmed/chemical/myomesin,
http://linkedlifedata.com/resource/pubmed/chemical/streptococcal M protein
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0023-852X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
634-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9149166-Adolescent,
pubmed-meshheading:9149166-Adult,
pubmed-meshheading:9149166-Antigens, Bacterial,
pubmed-meshheading:9149166-B-Lymphocytes,
pubmed-meshheading:9149166-Bacterial Outer Membrane Proteins,
pubmed-meshheading:9149166-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9149166-Carrier Proteins,
pubmed-meshheading:9149166-Child,
pubmed-meshheading:9149166-Child, Preschool,
pubmed-meshheading:9149166-Cytokines,
pubmed-meshheading:9149166-Female,
pubmed-meshheading:9149166-Humans,
pubmed-meshheading:9149166-Hypertrophy,
pubmed-meshheading:9149166-Immunity, Cellular,
pubmed-meshheading:9149166-Immunoglobulin A,
pubmed-meshheading:9149166-Immunoglobulin G,
pubmed-meshheading:9149166-Male,
pubmed-meshheading:9149166-Middle Aged,
pubmed-meshheading:9149166-Muscle Proteins,
pubmed-meshheading:9149166-Myeloma Proteins,
pubmed-meshheading:9149166-Palatine Tonsil,
pubmed-meshheading:9149166-Recurrence,
pubmed-meshheading:9149166-Streptococcus pyogenes,
pubmed-meshheading:9149166-Tonsillitis
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pubmed:year |
1997
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pubmed:articleTitle |
Immune responses against Streptococcus pyogenes in human palatine tonsils.
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pubmed:affiliation |
Department of Otolaryngology, Oita Medical University, Hasama-machi, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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