Linked Life Data

914830

Source:http://linkedlifedata.com/resource/pubmed/id/914830

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1977-12-29
pubmed:abstractText
Staphylococcal nuclease (micrococcal nuclease) and pancreatic DNase (DNase I) were used to digest HeLa chromatin core particles which had been labeled with 32P at their 5'-DNA termini. In contrast to DNase I, which cleaves core particle DNA at 10-nucleotide intervals from the 5' termini, staphylococcal nuclease cleaves core particle DNA at different sites, both fewer in number and less regularly spaced. Thus, it is unlikely that simple physical protection of DNA is the sole mechanism whereby chromosomal proteins restrict the nucleolytic cleavage of chromatin; furthermore, it seems likely that these nucleases may recognize different geometric configurations along the chromatin core particle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
252
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7635-9
pubmed:dateRevised
2001-3-23
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Staphylococcal nuclease and pancreatic DNase cleave the DNA within the chromatin core particle at different sites.
pubmed:publicationType
Journal Article