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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-7-18
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pubmed:abstractText |
In order to improve the surveillance of serogroup B and C meningococcal diseases, enzyme-linked immunosorbent assays (ELISAs) specific for anti-B immunoglobulin M (IgM) and anti-C IgM and IgG antibodies were developed. The tests were evaluated by using paired sera from 122 patients with and 101 patients without laboratory evidence of meningococcal disease. Fifty-three of 67 patients (79%) with culture-confirmed serogroup B disease had an anti-B IgM antibody response; anti-B IgM levels waned rapidly in children < or = 4 years of age. Twenty-four of 25 patients (96%) with culture-confirmed serogroup C disease had an anti-C IgM and/or IgG antibody response (IgM, 92%; IgG, 68%). In patients without evidence of meningococcal disease, 19% of children < or = 4 years of age and 69% of those > 4 years of age had intermediate anti-B IgM titers. In contrast, only 1 and 5% of these patients had intermediate titers of anti-C IgM and anti-C IgG, respectively. The ELISAs were shown to be powerful tools for discriminating between serogroup B and C diseases in 96 to 100% of culture-confirmed cases. For 90% of patients with culture-negative meningococcal disease, a serogroup-specific diagnosis could be established by examination of paired sera in the ELISAs. As serogroup B and C meningococci account for practically all cases of meningococcal disease in industrialized countries, the availability of these tests may improve surveillance and prevention.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-1422351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-1515823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-1734048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-1763793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-1812424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-1815335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-1908091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-1937795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-2655881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-408918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-4623401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-4977281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-6135869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-6431015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-6783703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-6818147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-7823383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-7834605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-8077392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-8360502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-8450238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9144375-8472774
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Capsules,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/capsular polysaccharide...,
http://linkedlifedata.com/resource/pubmed/chemical/meningococcal group C polysaccharide
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1071-412X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
345-51
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9144375-Adolescent,
pubmed-meshheading:9144375-Adult,
pubmed-meshheading:9144375-Aged,
pubmed-meshheading:9144375-Antibodies, Bacterial,
pubmed-meshheading:9144375-Antigens, Bacterial,
pubmed-meshheading:9144375-Bacterial Capsules,
pubmed-meshheading:9144375-Child,
pubmed-meshheading:9144375-Child, Preschool,
pubmed-meshheading:9144375-Denmark,
pubmed-meshheading:9144375-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:9144375-Humans,
pubmed-meshheading:9144375-Immunoglobulin G,
pubmed-meshheading:9144375-Immunoglobulin M,
pubmed-meshheading:9144375-Infant,
pubmed-meshheading:9144375-Meningitis, Meningococcal,
pubmed-meshheading:9144375-Meningococcal Infections,
pubmed-meshheading:9144375-Middle Aged,
pubmed-meshheading:9144375-Neisseria meningitidis,
pubmed-meshheading:9144375-Polysaccharides, Bacterial,
pubmed-meshheading:9144375-Serotyping
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pubmed:year |
1997
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pubmed:articleTitle |
Measurement of antibodies against meningococcal capsular polysaccharides B and C in enzyme-linked immunosorbent assays: towards an improved surveillance of meningococcal disease.
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pubmed:affiliation |
Neisseria Department, Statens Serum Institut, Copenhagen S., Denmark.
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pubmed:publicationType |
Journal Article
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