Linked Life Data

9135852

Source:http://linkedlifedata.com/resource/pubmed/id/9135852

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-5-27
pubmed:abstractText
To elevate the diagnostic value of the serum cytokeratin 19 fragment (CYFRA 21-1) and compare it with carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) in bronchogenic carcinoma, the sera of 161 patients (58 with benign pulmonary disease and 103 with bronchogenic carcinoma) was investigated using immunoradiometric assay. Sensitivities for CYFRA 21-1, CEA and TPA (using 3.5 ng ml-1, 5.0 ng ml-1, 110 U l-1, respectively, cut-off values corresponding to a 95% specificity for benign pulmonary disease) in bronchogenic carcinoma were 64, 47 and 61%, respectively. Positive CYFRA 21-1 levels were identified in 75% of patients with squamous cell carcinoma (n = 36), in 67% with adenocarcinoma (n = 45), in 17% with large cell carcinoma (n = 6), and in 50% with small cell lung cancer (SCLC) (n = 16). However, CYFRA 21-1 levels were not significantly different between squamous cell carcinoma and the other histological types. The sensitivity of the combined measurement of CYFRA 21-1 with any other tumour marker was significantly higher than that of CYFRA 21-1 measurement alone. Elevated CYFRA 21-1 levels were observed in 44% of Stages I and II (n = 18) and 72% of Stage III and IV (n = 69) patients with non-small cell lung cancer (P < 0.05). A significant inter-marker correlation was observed between CYFRA 21-1 and TPA (n = 103, r = 0.448, P < 0.0001). Twenty-one patients were monitored by CYFRA 21-1, and significantly different changes in progressive patients (P = 0.0058) and regressive patients (P = 0.016) were obtained. These results indicate that CYFRA 21-1 may be not only a sensitive tumour marker in the diagnosis of bronchogenic carcinoma, but also a useful marker for the monitoring of bronchogenic carcinoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0954-6111
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
135-42
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:9135852-Adenocarcinoma, pubmed-meshheading:9135852-Adolescent, pubmed-meshheading:9135852-Adult, pubmed-meshheading:9135852-Aged, pubmed-meshheading:9135852-Aged, 80 and over, pubmed-meshheading:9135852-Antigens, Neoplasm, pubmed-meshheading:9135852-Carcinoembryonic Antigen, pubmed-meshheading:9135852-Carcinoma, Bronchogenic, pubmed-meshheading:9135852-Carcinoma, Large Cell, pubmed-meshheading:9135852-Carcinoma, Small Cell, pubmed-meshheading:9135852-Carcinoma, Squamous Cell, pubmed-meshheading:9135852-Female, pubmed-meshheading:9135852-Humans, pubmed-meshheading:9135852-Immunoradiometric Assay, pubmed-meshheading:9135852-Keratin-19, pubmed-meshheading:9135852-Keratins, pubmed-meshheading:9135852-Lung Diseases, pubmed-meshheading:9135852-Lung Neoplasms, pubmed-meshheading:9135852-Male, pubmed-meshheading:9135852-Middle Aged, pubmed-meshheading:9135852-Sensitivity and Specificity, pubmed-meshheading:9135852-Tissue Polypeptide Antigen, pubmed-meshheading:9135852-Tumor Markers, Biological
pubmed:year
1997
pubmed:articleTitle
Comparison of cytokeratin fragment 19 (CYFRA 21-1), tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA) as tumour markers in bronchogenic carcinoma.
pubmed:affiliation
Department of Internal Medicine, Kaohsiung Medical College, Taiwan, Republic of China.
pubmed:publicationType
Journal Article, Comparative Study