rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
14
|
pubmed:dateCreated |
1997-5-23
|
pubmed:databankReference |
|
pubmed:abstractText |
Complementary DNA encoding the human CYR61 protein was isolated from human embryonic tissues and mapped to chromosome 1p22-p31. We show that CYR61 encodes a 381 amino acid protein rich in cysteine and proline residues that is strongly conserved with the mouse homologue. Sequence analysis reveals the presence of several distinct protein domains which confer a mosaic structure to this protein and makes human CYR61 a member of a recently described growth regulator family that includes several proto-oncogene products. From our results we hypothesize that this new immediate early gene may play a role in cell commitment during embryogenesis and more generally in the control of cell proliferation.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0950-9232
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
10
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1753-7
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:9135077-Base Sequence,
pubmed-meshheading:9135077-Chromosome Mapping,
pubmed-meshheading:9135077-Chromosomes, Human, Pair 1,
pubmed-meshheading:9135077-Cloning, Molecular,
pubmed-meshheading:9135077-Cysteine-Rich Protein 61,
pubmed-meshheading:9135077-Gene Expression,
pubmed-meshheading:9135077-Growth Substances,
pubmed-meshheading:9135077-Humans,
pubmed-meshheading:9135077-Immediate-Early Proteins,
pubmed-meshheading:9135077-In Situ Hybridization, Fluorescence,
pubmed-meshheading:9135077-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:9135077-Molecular Sequence Data,
pubmed-meshheading:9135077-RNA, Messenger,
pubmed-meshheading:9135077-Sequence Alignment,
pubmed-meshheading:9135077-Sequence Homology, Amino Acid
|
pubmed:year |
1997
|
pubmed:articleTitle |
The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.
|
pubmed:affiliation |
Centre de Recherche de Biochimie Macromolécularie, CNRS ERS 155-INSERMU249, Montpellier, France.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|