Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1997-5-19
|
| pubmed:abstractText |
To investigate the influence of human immunodeficiency virus (HIV) coinfection on preexisting long-term chronic C hepatitis (HCV) 68 liver biopsies from 22 HIV/HCV-coinfected, 13 HIV- and 33 HCV-monoinfected patients and 71 livers obtained at autopsy from 26 HIV/HCV-coinfected and 45 HIV-monoinfected patients were studied by histo- and immunohistochemistry. All HIV patients had reached the advanced stage of immunodeficiency (stage III CDC), except for 3 haemophilias (stage II CDC). HCV infection was associated with a higher degree of portal, periportal and lobular inflammation-regardless of whether there was concurrent HIV infection. HIV/HCV coinfection was associated with a significantly higher rate of granulocytic cholangiolitis than HCV and HIV monoinfection (P < 0.05), a histological feature uncommon in C hepatitis. In HIV/HCV coinfection cholestasis was a predominant histological feature. HCV monoinfection and HCV/HIV coinfection were associated with the highest fibrosis index. In HIV/HCV coinfection centrilobular fibrosis was significantly more marked than in HCV monoinfection (P < 0.05), suggesting an HIV-associated fibrogenic effect. Patients with chronic C hepatitis showed a significantly increased rate of posthepatitic cirrhosis compared with the patients without HCV infection (P < 0.05). At autopsy, 10 of the 20 HIV/HCV-coinfected haemophiliacs had developed cirrhosis because of chronic C hepatitis, whereas cirrhosis was found in only 2 of 6 HIV/HCV-coinfected non-haemophiliacs (1 case of chronic B and C hepatitis, and 1 case of chronic alcohol abuse). No cirrhosis was observed in the 45 autopsy patients with HIV monoinfection. The findings suggest that HIV coinfection aggravates the course of preceding long-term chronic C hepatitis by a more marked (centrilobular) fibrosis. HIV/HCV-coinfected patients are threatened by a higher rate of posthepatitic cirrhosis-particularly in multitransfused haemophiliacs-and cholestatic hepatopathy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0945-6317
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
430
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
271-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9134037-Adolescent,
pubmed-meshheading:9134037-Adult,
pubmed-meshheading:9134037-Aged,
pubmed-meshheading:9134037-Biopsy,
pubmed-meshheading:9134037-Cholangitis,
pubmed-meshheading:9134037-Chronic Disease,
pubmed-meshheading:9134037-Female,
pubmed-meshheading:9134037-HIV Infections,
pubmed-meshheading:9134037-Hepatitis C,
pubmed-meshheading:9134037-Humans,
pubmed-meshheading:9134037-Liver,
pubmed-meshheading:9134037-Liver Cirrhosis,
pubmed-meshheading:9134037-Liver Diseases,
pubmed-meshheading:9134037-Male,
pubmed-meshheading:9134037-Middle Aged
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Liver histopathology in patients with concurrent chronic hepatitis C and HIV infection.
|
| pubmed:affiliation |
Department of Pathology, University of Bonn, Germany.
|
| pubmed:publicationType |
Journal Article
|