rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1997-5-1
|
pubmed:abstractText |
Delta-6 desaturase was measured in rat brain microvessels and choroid plexus by incubation in the presence of radioactive linoleic acid. Under our conditions, in 21-day-old animals, delta-6 desaturase was not detected in brain microvessels. In contrast, it was present in choroid plexus (about 21 pmol/min per mg protein). In comparison, the activity in brain was much lower (about 1 pmol/min per mg protein) and higher in liver (about 55 pmol/min per mg protein). Interestingly, during development the activity in choroid plexus peaked at day 6 after birth and declined slightly thereafter. The pattern of incorporation of linoleic acid radioactivity was not the same in choroid plexus and microvessels. These results show that delta-6 desaturase was not detected in brain microvessels but was present in choroid plexus.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0304-3940
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
7
|
pubmed:volume |
224
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1-4
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:9132678-Aging,
pubmed-meshheading:9132678-Animals,
pubmed-meshheading:9132678-Animals, Newborn,
pubmed-meshheading:9132678-Brain,
pubmed-meshheading:9132678-Capillaries,
pubmed-meshheading:9132678-Cerebrovascular Circulation,
pubmed-meshheading:9132678-Choroid Plexus,
pubmed-meshheading:9132678-Fatty Acid Desaturases,
pubmed-meshheading:9132678-Fatty Acids, Unsaturated,
pubmed-meshheading:9132678-Linoleic Acid,
pubmed-meshheading:9132678-Linoleic Acids,
pubmed-meshheading:9132678-Linoleoyl-CoA Desaturase,
pubmed-meshheading:9132678-Rats
|
pubmed:year |
1997
|
pubmed:articleTitle |
Possible role of the choroid plexus in the supply of brain tissue with polyunsaturated fatty acids.
|
pubmed:affiliation |
INSERM U 26, Hôpital Fernand Widal, Paris, France.
|
pubmed:publicationType |
Journal Article,
In Vitro
|