Linked Life Data

9126959

Source:http://linkedlifedata.com/resource/pubmed/id/9126959

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pubmed-article:9126959pubmed:abstractTextTo examine the structural basis for the specific recognition of the MHC class I allotypes HLA-Cw*0401 and HLA-Cw*0304 by the killer cell inhibitory receptors (KIR) cl42 and cl43, respectively, mutant KIR-Ig fusion proteins were tested by direct binding to cells transfected with single HLA-C alleles. The putative loop region at position 44-46 of KIR contained amino acids that were necessary for the discrimination between HLA-Cw*0401 and HLA-Cw*0304. Surprisingly, exchanging the methionine at position 44 in cl42 with the lysine at position 44 in cl43 was sufficient to switch the specificity of cl42 from HLA-Cw*0401 to HLA-Cw*0304, and vice versa. Thus, a single amino acid in the first Ig domain of these KIR determines their ability to discriminate between the two groups of HLA-C allotypes.lld:pubmed
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pubmed-article:9126959pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:9126959pubmed:articleTitleA single amino acid in the p58 killer cell inhibitory receptor controls the ability of natural killer cells to discriminate between the two groups of HLA-C allotypes.lld:pubmed
pubmed-article:9126959pubmed:affiliationLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.lld:pubmed
pubmed-article:9126959pubmed:publicationTypeJournal Articlelld:pubmed
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