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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-7-30
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pubmed:abstractText |
Primary biliary cirrhosis is a chronic cholestatic liver disease in which autoreactive T cells may play an important role in the destruction of intrahepatic bile ducts. However, target antigens remain unknown. Alpha-enolase-derived peptide binds to human leukocyte antigen (HLA)-DR8, which is implicated in the development of primary biliary cirrhosis in Japanese patients. Partial homology between alpha-enolase and the inner lipoyl domain of E2 component of pyruvate dehydrogenase (PDH-E2) is also observed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0168-8278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
845-51
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9126798-Acute Disease,
pubmed-meshheading:9126798-Animals,
pubmed-meshheading:9126798-Antibody Specificity,
pubmed-meshheading:9126798-Autoantibodies,
pubmed-meshheading:9126798-Autoimmune Diseases,
pubmed-meshheading:9126798-Chronic Disease,
pubmed-meshheading:9126798-Female,
pubmed-meshheading:9126798-Hepatitis,
pubmed-meshheading:9126798-Hepatitis, Viral, Human,
pubmed-meshheading:9126798-Humans,
pubmed-meshheading:9126798-Immunoblotting,
pubmed-meshheading:9126798-Isoenzymes,
pubmed-meshheading:9126798-Liver Cirrhosis, Biliary,
pubmed-meshheading:9126798-Male,
pubmed-meshheading:9126798-Middle Aged,
pubmed-meshheading:9126798-Phosphopyruvate Hydratase,
pubmed-meshheading:9126798-Pyruvate Dehydrogenase Complex,
pubmed-meshheading:9126798-Rabbits,
pubmed-meshheading:9126798-Reference Values
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pubmed:year |
1997
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pubmed:articleTitle |
Identification of an autoantibody against alpha-enolase in primary biliary cirrhosis.
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pubmed:affiliation |
The First Department of Internal Medicine, Kochi Medical School, Nankoku, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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