Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-5-15
pubmed:abstractText
Nitric oxide (NO) produced by inducible NO synthase (iNOS) mediates hypotension in endotoxemia. In this study, NO induction by a toxin-producing Streptococcus pyogenes isolate, H250, and by recombinant streptococcal pyrogenic exotoxin A (rSPEA) has been examined, both in vitro and in vivo. Streptococcal supernatants, but not rSPEA, induce production of nitrite by murine macrophages when both are coincubated with gamma interferon. Intraperitoneal injection of rSPEA did not cause significant production of NO. However, an elevated level of nitrate in serum was detected in a model of streptococcal fasciitis due to live H250. iNOS was localized to Kupffer cells, hepatocytes, and renal tubular cells by immunostaining. Administration of a NOS inhibitor, N(G)-monomethyl-L-arginine (L-NMMA), reduced peak concentrations of nitrate in serum but did not affect survival. NO is induced by H250, both in vitro and in vivo, mainly via SPEA-independent mechanisms. In this model, iNOS is expressed predominantly in the liver. Furthermore, in this model L-NMMA is not protective.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-1282952, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-1283860, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-1372433, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-1457672, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-14954103, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-1569337, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-1571429, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-1711326, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-1852778, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-1884398, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-2206394, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-2226626, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-2358781, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-3374833, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-4056039, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-6527651, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-6811417, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-7181105, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-7507664, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-7508968, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-7516310, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-7520469, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-7526041, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-7684416, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-7798684, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-8039877, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-8063387, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-8149966, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-8215727, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-8253961, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-8335368, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-8355123, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-8406805, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-8648212, http://linkedlifedata.com/resource/pubmed/commentcorrection/9125560-8786301
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1767-72
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:9125560-Animals, pubmed-meshheading:9125560-Cells, Cultured, pubmed-meshheading:9125560-Exotoxins, pubmed-meshheading:9125560-Immunohistochemistry, pubmed-meshheading:9125560-Interferon-gamma, pubmed-meshheading:9125560-Kidney, pubmed-meshheading:9125560-Kupffer Cells, pubmed-meshheading:9125560-Liver, pubmed-meshheading:9125560-Macrophages, Peritoneal, pubmed-meshheading:9125560-Male, pubmed-meshheading:9125560-Mice, pubmed-meshheading:9125560-Nitrates, pubmed-meshheading:9125560-Nitric Oxide, pubmed-meshheading:9125560-Nitric Oxide Synthase, pubmed-meshheading:9125560-Nitrites, pubmed-meshheading:9125560-Recombinant Proteins, pubmed-meshheading:9125560-Sepsis, pubmed-meshheading:9125560-Streptococcal Infections, pubmed-meshheading:9125560-Streptococcus pyogenes, pubmed-meshheading:9125560-omega-N-Methylarginine
pubmed:year
1997
pubmed:articleTitle
The role of nitric oxide in experimental murine sepsis due to pyrogenic exotoxin A-producing Streptococcus pyogenes.
pubmed:affiliation
Department of Infectious Diseases, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom.
pubmed:publicationType
Journal Article
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