Linked Life Data

9124564

Source:http://linkedlifedata.com/resource/pubmed/id/9124564

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3 Pt 1
pubmed:dateCreated
1997-4-24
pubmed:abstractText
Rates of fructose uptake by the small intestine of neonatal rats are typically very low from parturition through weaning but undergo a dramatic increase immediately after weaning is completed. In this study, we used intestinal fructose transport as a model to determine whether nutrient transport, normally enhanced only after completion of weaning, can be enhanced earlier during development. We found that ontogenetic changes in levels of GLUT5 mRNA correlate well with already known ontogenetic changes in rates of intestinal fructose transport: low levels and rates during suckling and weaning, and high levels and rates after weaning. In contrast, levels of GLUT2 and SGLT1 mRNA were relatively more elevated throughout the suckling and weaning periods. We then found that increased expression of GLUT5 mRNA caused by dietary fructose or sucrose paralleled diet-dependent increases in brush-border fructose uptake. Rates of brush-border glucose uptake and levels of SGLT1 and GLUT2 mRNA were not enhanced by dietary fructose, glucose, or sucrose. Finally, we found that rates of fructose uptake, levels of GLUT5 mRNA, and specific sucrase activity each increased with increasing concentrations of dietary fructose given precociously to midweaning rats. In contrast, brush-border glucose uptake was independent of dietary fructose concentration. Thus precocious introduction of dietary fructose causes enhanced expression of fructose transporters earlier during development. This effect is specific: only luminal fructose is effective, and only brush-border fructose transport can be modulated. These results unveil the potential for regulating nutrient transport early in development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
272
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G446-53
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:9124564-Age Factors, pubmed-meshheading:9124564-Animals, pubmed-meshheading:9124564-Dietary Carbohydrates, pubmed-meshheading:9124564-Female, pubmed-meshheading:9124564-Fructose, pubmed-meshheading:9124564-Gene Expression, pubmed-meshheading:9124564-Glucose Transporter Type 2, pubmed-meshheading:9124564-Glucose Transporter Type 5, pubmed-meshheading:9124564-Intestinal Absorption, pubmed-meshheading:9124564-Intestine, Small, pubmed-meshheading:9124564-Jejunum, pubmed-meshheading:9124564-Male, pubmed-meshheading:9124564-Membrane Glycoproteins, pubmed-meshheading:9124564-Monosaccharide Transport Proteins, pubmed-meshheading:9124564-RNA, Messenger, pubmed-meshheading:9124564-Rats, pubmed-meshheading:9124564-Rats, Sprague-Dawley, pubmed-meshheading:9124564-Sodium-Glucose Transporter 1, pubmed-meshheading:9124564-Weaning
pubmed:year
1997
pubmed:articleTitle
Dietary fructose enhances intestinal fructose transport and GLUT5 expression in weaning rats.
pubmed:affiliation
Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't