Linked Life Data

9124497

Source:http://linkedlifedata.com/resource/pubmed/id/9124497

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 2
pubmed:dateCreated
1997-4-22
pubmed:abstractText
Bladder afferent nerve activity was recorded from the pelvic and hypogastric nerves of rats anesthetized with pentobarbital sodium. Bladder filling with isotonic NaCl at a rate of 250 microl/min excited multiunit afferent activity in the hypogastric nerve by 190 +/- 38% over background at a pressure of 30 mmHg, whereas 150 meq/l KCl at the same filling rate excited hypogastric nerve activity by 498 +/- 103% (P < 0.0001). This difference was localized to a group of chemosensitive fibers that are excited by bladder filling with KCl in a concentration-dependent fashion but are insensitive to bladder filling with NaCl. Bladder filling with 200 meq/l KCl at different filling rates caused a bursting pattern of discharge in these fibers at consistent bladder volumes but with a pressure threshold that increased proportionately with filling rate. Other hypogastric bladder afferent fibers were activated to a similar extent by NaCl and KCl solutions. Chemoreceptive bladder afferent fibers were rare in the pelvic nerve (1 of 15 units), and multiunit preparations showed comparable excitations during bladder filling with NaCl and KCl solutions. The bursting activation of bladder chemoreceptive afferent nerves in hypogastric nerves could signal noxious overdistension and/or inflammation of the bladder.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
272
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R695-703
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Pressure, volume, and chemosensitivity in afferent innervation of urinary bladder in rats.
pubmed:affiliation
Department of Physiology, University of North Carolina, Chapel Hill 27599-7545, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.