Linked Life Data

9121222

Source:http://linkedlifedata.com/resource/pubmed/id/9121222

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1997-4-21
pubmed:abstractText
The effect of various inhibitors of nitric oxide synthase (NOS) on three cell lines with osteoblastic phenotype was studied. N-Mono-methyl arginine (NMMA) inhibited the growth of MG63 and ROS 17/2.8 cells, and N-iminoethyl-ornithine (NIO) inhibited the growth of ROS 17/2.8. However, N-nitro-arginine (NA) and N-nitro-arginine-methyl ester (NAME) had no effect. None of the NOS inhibitors affected MC3T3 growth, in spite of blocking NO synthesis. NMMA and NIO also caused a marked decrease of arginine uptake by the three cell lines studied. These results indicate that some NOS inhibitors have antiproliferative effects which do not seem to be related to the inhibition of NOS activity or arginine uptake.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0379-0355
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
663-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Impairment of osteoblast growth by nitric oxide synthase inhibitors: an effect independent of nitric oxide and arginine transport inhibition.
pubmed:affiliation
Department of Internal Medicine, Hospital U.M. Valdecilla, University of Cantabria, Santander, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't