| pubmed-article:911983 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:911983 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:911983 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:911983 | lifeskim:mentions | umls-concept:C0039593 | lld:lifeskim |
| pubmed-article:911983 | lifeskim:mentions | umls-concept:C0022885 | lld:lifeskim |
| pubmed-article:911983 | lifeskim:mentions | umls-concept:C0425245 | lld:lifeskim |
| pubmed-article:911983 | lifeskim:mentions | umls-concept:C1441506 | lld:lifeskim |
| pubmed-article:911983 | lifeskim:mentions | umls-concept:C0008813 | lld:lifeskim |
| pubmed-article:911983 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:911983 | pubmed:dateCreated | 1977-12-29 | lld:pubmed |
| pubmed-article:911983 | pubmed:abstractText | Previous calculations using crystal structure coordinates (Strickland and Mercola [1976], Biochemistry. 15: 3857) have predicted that about 40 percent of the calculated tyrosyl circular dichroism of hexameric insulin is due to one of the four tyrosine residues: viz. the A14-tyrosine interacting with the nearby B1-phenylalanine ring group. We have tested this prediction by measuring the tyrosyl circular dichroism of an isomorphous analogue of insulin, des-B1-phenylalanine-insulin. Contrary to expectation, the resulting circular dichroism was the same as that of insulin. It is concluded that the B1-phenylalanine residue does not in fact make a large contribution to the circular dichroism of A14-tyrosine. This result is probably due to the thermal motion of the B1 and A14 ring groups not taken into account by the calculations. An example of the effects of thermal motion on the calculated circular dichroism is given and improvements that do take into account thermal motion are discussed. | lld:pubmed |
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| pubmed-article:911983 | pubmed:language | eng | lld:pubmed |
| pubmed-article:911983 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:911983 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:911983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:911983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:911983 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:911983 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:911983 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:911983 | pubmed:author | pubmed-author:WollmerAA | lld:pubmed |
| pubmed-article:911983 | pubmed:author | pubmed-author:FleischhauerJ... | lld:pubmed |
| pubmed-article:911983 | pubmed:author | pubmed-author:ThieleHH | lld:pubmed |
| pubmed-article:911983 | pubmed:author | pubmed-author:StrassburgerW... | lld:pubmed |
| pubmed-article:911983 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:911983 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:911983 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:911983 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:911983 | pubmed:pagination | 233-43 | lld:pubmed |
| pubmed-article:911983 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:911983 | pubmed:meshHeading | pubmed-meshheading:911983-I... | lld:pubmed |
| pubmed-article:911983 | pubmed:meshHeading | pubmed-meshheading:911983-P... | lld:pubmed |
| pubmed-article:911983 | pubmed:meshHeading | pubmed-meshheading:911983-M... | lld:pubmed |
| pubmed-article:911983 | pubmed:meshHeading | pubmed-meshheading:911983-P... | lld:pubmed |
| pubmed-article:911983 | pubmed:meshHeading | pubmed-meshheading:911983-M... | lld:pubmed |
| pubmed-article:911983 | pubmed:meshHeading | pubmed-meshheading:911983-C... | lld:pubmed |
| pubmed-article:911983 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:911983 | pubmed:articleTitle | Side-chain mobility and the calculation of tyrosyl circular dichroism of proteins. Implications of a test with insulin and des-B1-phenylalanine insulin. | lld:pubmed |
| pubmed-article:911983 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:911983 | lld:pubmed |
