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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0024432,
umls-concept:C0026336,
umls-concept:C0034493,
umls-concept:C0128897,
umls-concept:C0185117,
umls-concept:C0221464,
umls-concept:C0332448,
umls-concept:C0521447,
umls-concept:C1292733,
umls-concept:C1524081,
umls-concept:C1849618,
umls-concept:C1879547,
umls-concept:C2911684
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|
pubmed:issue |
6
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|
pubmed:dateCreated |
1997-4-24
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|
pubmed:abstractText |
The migration of monocytes into the vessel wall is a critical event leading to the development of atherosclerosis. Monocyte chemoattractant protein-1 (MCP-1) is the main chemotactic factor involved in this phenomenon, and nuclear factor-kappa B (NF-kappa B) is one of the nuclear factors controlling its expression. ACE inhibitors have been useful in some experimental models of atherosclerosis. In this work, we addressed the hypothesis that angiotensin II (Ang II) may be implicated in the recruitment of monocytes into the vessel wall through the activation of NF-kappa B and the induction of MCP-1 expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-7322
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
95
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1532-41
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9118522-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:9118522-Animals,
pubmed-meshheading:9118522-Arteriosclerosis,
pubmed-meshheading:9118522-Cell Movement,
pubmed-meshheading:9118522-Cells, Cultured,
pubmed-meshheading:9118522-Chemokine CCL2,
pubmed-meshheading:9118522-Femoral Artery,
pubmed-meshheading:9118522-Gene Expression,
pubmed-meshheading:9118522-Immunohistochemistry,
pubmed-meshheading:9118522-Isoquinolines,
pubmed-meshheading:9118522-Macrophages,
pubmed-meshheading:9118522-Male,
pubmed-meshheading:9118522-Monocytes,
pubmed-meshheading:9118522-Muscle, Smooth, Vascular,
pubmed-meshheading:9118522-NF-kappa B,
pubmed-meshheading:9118522-Peptidyl-Dipeptidase A,
pubmed-meshheading:9118522-Rabbits,
pubmed-meshheading:9118522-Tetrahydroisoquinolines
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pubmed:year |
1997
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pubmed:articleTitle |
Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-kappa B activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis.
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pubmed:affiliation |
Research Laboratory, Fundación Jiménez Díaz, Autonoma University, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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