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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-6-13
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pubmed:abstractText |
The value of daily monitoring of the blood CD34+ cell concentration as a guide to the optimal timing of stem cell harvests was studied in 60 patients who underwent 66 stem cell mobilizations and 189 leukaphereses. There was a highly significant correlation between the blood CD34+ count and the CD34+ cell content in the apheresis product of the same day (r = 0.904, p < 0.01). Thus, the target yield of 4 x 10(6) CD34+ cells/kg can be harvested in one or two leukaphereses when the blood CD34+ cell count exceeds 50 x 10(6)/L. However, an insufficient harvest is to be expected when the blood CD34+ cell count is below 20 x 10(6)/L. The data from 35 autologous blood cell transplantations with a minimum CD34+ cell yield of 1.5 x 10(6)/kg showed that the recovery of blood neutrophil counts to 1.0 x 10(9)/L occurred in all patients within 9-14 days, but the time to recovery of the platelet counts to 20 x 10(9)/L may exceed 14 days, especially if the CD34+ cell content is below 4 x 10(6)/kg. Daily monitoring of blood CD34+ cell counts is a rapid and reliable means to guide the timing of stem cell collections. The count predicts well the CD34+ cell content of the harvests, the number of leukaphereses needed, and the speed of hematopoietic recovery.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1061-6128
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9112214-Adult,
pubmed-meshheading:9112214-Aged,
pubmed-meshheading:9112214-Antigens, CD,
pubmed-meshheading:9112214-Antigens, CD34,
pubmed-meshheading:9112214-Antineoplastic Agents,
pubmed-meshheading:9112214-Biological Markers,
pubmed-meshheading:9112214-Blood Component Removal,
pubmed-meshheading:9112214-Blood Transfusion, Autologous,
pubmed-meshheading:9112214-Breast Neoplasms,
pubmed-meshheading:9112214-Cyclophosphamide,
pubmed-meshheading:9112214-Female,
pubmed-meshheading:9112214-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:9112214-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:9112214-Hematopoiesis,
pubmed-meshheading:9112214-Hematopoietic Stem Cells,
pubmed-meshheading:9112214-Hodgkin Disease,
pubmed-meshheading:9112214-Humans,
pubmed-meshheading:9112214-Leukocyte Count,
pubmed-meshheading:9112214-Lymphoma,
pubmed-meshheading:9112214-Lymphoma, Non-Hodgkin,
pubmed-meshheading:9112214-Middle Aged,
pubmed-meshheading:9112214-Monitoring, Immunologic,
pubmed-meshheading:9112214-Multiple Myeloma,
pubmed-meshheading:9112214-Neoplasms,
pubmed-meshheading:9112214-Neutrophils,
pubmed-meshheading:9112214-Ovarian Neoplasms,
pubmed-meshheading:9112214-Predictive Value of Tests,
pubmed-meshheading:9112214-Regression Analysis,
pubmed-meshheading:9112214-Reproducibility of Results
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pubmed:year |
1997
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pubmed:articleTitle |
Daily measurements of blood CD34+ cells after stem cell mobilization predict stem cell yield and posttransplant hematopoietic recovery.
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pubmed:affiliation |
Department of Medicine, Turku University Central Hospital, Finland.
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pubmed:publicationType |
Journal Article
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