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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5312
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pubmed:dateCreated |
1997-5-9
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pubmed:abstractText |
The gene encoding the BCL-6 transcriptional repressor is frequently translocated and mutated in diffuse large cell lymphoma. Mice with a disrupted BCL-6 gene developed myocarditis and pulmonary vasculitis, had no germinal centers, and had increased expression of T helper cell type 2 cytokines. The BCL-6 DNA recognition motif resembled sites bound by the STAT (signal transducers and activators of transcription) transcription factors, which mediate cytokine signaling. BCL-6 could repress interleukin-4 (IL-4)-induced transcription when bound to a site recognized by the IL-4-responsive transcription factor Stat6. Thus, dysregulation of STAT-responsive genes may underlie the inflammatory disease in BCL-6-deficient mice and participate in lymphoid malignancies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ficoll,
http://linkedlifedata.com/resource/pubmed/chemical/Hemocyanin,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-6,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/STAT6 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/TNP-ficoll,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Trinitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/trinitrophenyl keyhole limpet...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
276
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
589-92
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9110977-Animals,
pubmed-meshheading:9110977-B-Lymphocytes,
pubmed-meshheading:9110977-Cells, Cultured,
pubmed-meshheading:9110977-Cytokines,
pubmed-meshheading:9110977-DNA-Binding Proteins,
pubmed-meshheading:9110977-Ficoll,
pubmed-meshheading:9110977-Germinal Center,
pubmed-meshheading:9110977-Hemocyanin,
pubmed-meshheading:9110977-Immunoglobulins,
pubmed-meshheading:9110977-Inflammation,
pubmed-meshheading:9110977-Interferon-gamma,
pubmed-meshheading:9110977-Interleukin-4,
pubmed-meshheading:9110977-Interleukins,
pubmed-meshheading:9110977-Lymphocyte Activation,
pubmed-meshheading:9110977-Mice,
pubmed-meshheading:9110977-Myocarditis,
pubmed-meshheading:9110977-Proto-Oncogene Proteins,
pubmed-meshheading:9110977-Proto-Oncogene Proteins c-bcl-6,
pubmed-meshheading:9110977-Receptors, IgE,
pubmed-meshheading:9110977-STAT6 Transcription Factor,
pubmed-meshheading:9110977-Signal Transduction,
pubmed-meshheading:9110977-Spleen,
pubmed-meshheading:9110977-T-Lymphocytes,
pubmed-meshheading:9110977-Th2 Cells,
pubmed-meshheading:9110977-Trans-Activators,
pubmed-meshheading:9110977-Transcription, Genetic,
pubmed-meshheading:9110977-Transcription Factors,
pubmed-meshheading:9110977-Trinitrobenzenes,
pubmed-meshheading:9110977-Vasculitis
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pubmed:year |
1997
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pubmed:articleTitle |
Control of inflammation, cytokine expression, and germinal center formation by BCL-6.
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pubmed:affiliation |
Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article
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