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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0035553,
umls-concept:C0036025,
umls-concept:C0205314,
umls-concept:C0220781,
umls-concept:C0679622,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1883254
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pubmed:issue |
2
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pubmed:dateCreated |
1997-5-20
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pubmed:databankReference |
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pubmed:abstractText |
We isolated a temperature-sensitive mutant of Saccharomyces cerevisiae in which transcription both of ribosomal protein genes and of ribosomal RNA is defective at the non-permissive temperature. Temperature-sensitivity for growth is recessive and segregates 2:2. The wild type gene, termed RIC1 (for ribosome control) was cloned by complementation of the temperature-sensitive phenotype from a genomic DNA library based on the CEN plasmid. RIC1 encodes a protein of 1056 amino acid (aa) residues including a putative nuclear localization sequence. Data base searches revealed that RIC1 is a novel gene and predicted aa sequence share some sequence similarity with viral transcriptional regulatory proteins.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Fungal,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoside Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Guanine Nucleotide Exchange Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Localization Signals,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Ribosomal,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Fructofuranosidase
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0378-1119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
187
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
171-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9099877-Amino Acid Sequence,
pubmed-meshheading:9099877-Animals,
pubmed-meshheading:9099877-Base Sequence,
pubmed-meshheading:9099877-Chromosome Mapping,
pubmed-meshheading:9099877-Cloning, Molecular,
pubmed-meshheading:9099877-DNA, Fungal,
pubmed-meshheading:9099877-Fungal Proteins,
pubmed-meshheading:9099877-Genes, Fungal,
pubmed-meshheading:9099877-Glycoside Hydrolases,
pubmed-meshheading:9099877-Guanine Nucleotide Exchange Factors,
pubmed-meshheading:9099877-Membrane Proteins,
pubmed-meshheading:9099877-Molecular Sequence Data,
pubmed-meshheading:9099877-Mutation,
pubmed-meshheading:9099877-Nuclear Localization Signals,
pubmed-meshheading:9099877-Nuclear Proteins,
pubmed-meshheading:9099877-RNA, Ribosomal,
pubmed-meshheading:9099877-Ribosomal Proteins,
pubmed-meshheading:9099877-Ribosomes,
pubmed-meshheading:9099877-Saccharomyces cerevisiae,
pubmed-meshheading:9099877-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:9099877-Temperature,
pubmed-meshheading:9099877-Transcription, Genetic,
pubmed-meshheading:9099877-Transcription Factors,
pubmed-meshheading:9099877-beta-Fructofuranosidase
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pubmed:year |
1997
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pubmed:articleTitle |
RIC1, a novel gene required for ribosome synthesis in Saccharomyces cerevisiae.
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pubmed:affiliation |
Department of Biochemistry and Biophysics, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Japan. kmizuta@ipc.hiroshima-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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