| pubmed-article:9084411 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C0027836 | lld:lifeskim |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C0017626 | lld:lifeskim |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C0207071 | lld:lifeskim |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C1150611 | lld:lifeskim |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C1707310 | lld:lifeskim |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C0205548 | lld:lifeskim |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9084411 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9084411 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9084411 | pubmed:dateCreated | 1997-4-28 | lld:pubmed |
| pubmed-article:9084411 | pubmed:abstractText | In recent reports, ciliary neurotrophic factor (CNTF) has been implicated as an injury factor involved in regulating astrogliosis in the CNS. In this study, we used a rat oligodendroglial progenitor cell line that is highly responsive to CNTF to examine CNTF-induced alterations that may play a role in activation of the glial fibrillary acidic protein (GFAP) gene. We determined that CNTF induces the transient translocation of Stat1 alpha/p91 to the nucleus. This nuclear translocation was followed by GFAP promoter activation and an up-regulation of GFAP mRNA and protein. Level of CNTF-alpha receptor mRNA, however, were unaffected by addition of the ligand. Transfection studies using an upstream 5'-flanking, 1.9-kb rat GFAP promoter linked to a luciferase reporter gene revealed CNTF-induced transcriptional activation within 1 h of ligand exposure. Moreover, serial-deleted constructs identified a distal (-1,857 to -1,546 bp) and a proximal (-384 to -106 bp) region as being important for CNTF-induced GFAP promoter activation. These two regions showed a strong degree of overlap for CNTF- and serum-induced activation of the GFAP gene. Analysis of the two regions revealed several cis-elements that are thought to be involved in GFAP regulation and/or the regulation of other genes by members of the interleukin-6 family of cytokines. Moreover, we are the first to report the presence of several putative CNTF-responsive elements within our identified distal and proximal regions in the GFAP gene promoter. | lld:pubmed |
| pubmed-article:9084411 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9084411 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9084411 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9084411 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9084411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9084411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9084411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9084411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9084411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9084411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9084411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9084411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9084411 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9084411 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9084411 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:9084411 | pubmed:author | pubmed-author:CarusoAA | lld:pubmed |
| pubmed-article:9084411 | pubmed:author | pubmed-author:de VellisJJ | lld:pubmed |
| pubmed-article:9084411 | pubmed:author | pubmed-author:BarresiVV | lld:pubmed |
| pubmed-article:9084411 | pubmed:author | pubmed-author:KahnM AMA | lld:pubmed |
| pubmed-article:9084411 | pubmed:author | pubmed-author:HuangC JCJ | lld:pubmed |
| pubmed-article:9084411 | pubmed:author | pubmed-author:CondorelliD... | lld:pubmed |
| pubmed-article:9084411 | pubmed:author | pubmed-author:NazarianRR | lld:pubmed |
| pubmed-article:9084411 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9084411 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:9084411 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9084411 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9084411 | pubmed:pagination | 1413-23 | lld:pubmed |
| pubmed-article:9084411 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9084411 | pubmed:meshHeading | pubmed-meshheading:9084411-... | lld:pubmed |
| pubmed-article:9084411 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9084411 | pubmed:articleTitle | Ciliary neurotrophic factor activates JAK/Stat signal transduction cascade and induces transcriptional expression of glial fibrillary acidic protein in glial cells. | lld:pubmed |
| pubmed-article:9084411 | pubmed:affiliation | Department of Neurobiology, UCLA School of Medicine 90024-1764, USA. | lld:pubmed |
| pubmed-article:9084411 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9084411 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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