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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1997-4-29
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pubmed:databankReference |
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pubmed:abstractText |
A plasmid library of Neisseria gonorrhoeae sequences was screened for the ability to mediate recombinations on a sequence containing the Moraxella lacunata type 4 pilin gene invertible region in Escherichia coli. A plasmid containing the N. gonorrhoeae sequence encoding the putative recombinase (gcr) was identified and sequenced. Plasmids containing gcr were able to mediate site-specific recombinations despite a weak amino acid homology to Piv, the native M. lacunata pilin gene invertase. The gcr gene is present only in pathogenic strains of Neisseria tested; however, in our assays gene knockouts of gcr did not alter the variation of surface features that play a role in the pathogenesis of N. gonorrhoeae.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9079926-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9079926-1484481,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
179
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2382-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9079926-Amino Acid Sequence,
pubmed-meshheading:9079926-Bacterial Outer Membrane Proteins,
pubmed-meshheading:9079926-Bacterial Proteins,
pubmed-meshheading:9079926-Base Sequence,
pubmed-meshheading:9079926-Cloning, Molecular,
pubmed-meshheading:9079926-DNA, Bacterial,
pubmed-meshheading:9079926-DNA Nucleotidyltransferases,
pubmed-meshheading:9079926-Fimbriae Proteins,
pubmed-meshheading:9079926-Gene Expression Regulation, Bacterial,
pubmed-meshheading:9079926-Genes, Bacterial,
pubmed-meshheading:9079926-Molecular Sequence Data,
pubmed-meshheading:9079926-Moraxella,
pubmed-meshheading:9079926-Neisseria gonorrhoeae,
pubmed-meshheading:9079926-Promoter Regions, Genetic,
pubmed-meshheading:9079926-Recombination, Genetic,
pubmed-meshheading:9079926-Species Specificity
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pubmed:year |
1997
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pubmed:articleTitle |
Inversion of Moraxella lacunata type 4 pilin gene sequences by a Neisseria gonorrhoeae site-specific recombinase.
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pubmed:affiliation |
Department of Microbiology, Biozentrum, University of Basel, Switzerland. rozsa@umich.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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