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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1997-4-15
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pubmed:abstractText |
Adipocytes represent an important source of angiotensiongen (AT). Angiotensin II (A-II) stimulates in vitro and in vivo the formation and release of prostacyclin which acts as a potent adipogenic signal in triggering the terminal differentiation of preadipocytes into adipocytes [Darimont, Vassaux, Gaillard. Ailhaud and Négrel (1994) Int. J. Obes. 18, 783-788]. Since fatty acids have been reported to activate in preadipose cells the expression of various differentiation-dependent genes, the role of fatty acids in the regulation of AT gene expression was investigated. Long-chain natural and non-metabolized fatty acids as well as peroxisome proliferators behave as activators of AT gene expression. Accumulation of AT mRNA parallels that of the adipocyte fatty acid-binding protein gene and is primarily due to transcriptional activation of the AT gene. AT mRNA decreases after fatty acid removal (half-life approx. 8 h). Secretion of AT is also observed but appears mainly as a late differentiation-dependent phenomenon. Thus the AT gene appears to be a fatty acid-responsive gene; this regulation provides a potential link between the flux of fatty acids and the potential of adipose tissue to produce AT and possibly A-II.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-1316614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-1438299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-1651843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-1753215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-1885777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-1999356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-2045166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-2129546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-2351437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-2465693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-2722862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-2839415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-3013940,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-3383369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-3665835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-3800927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-4020123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-4504350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-7592593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-7659092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-7671018,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9078267-8670068
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensinogen,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fabp5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fabp7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fabp7 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin P2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/peroxisome proliferator-binding...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
322 ( Pt 1)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
235-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9078267-Adipocytes,
pubmed-meshheading:9078267-Angiotensinogen,
pubmed-meshheading:9078267-Animals,
pubmed-meshheading:9078267-Carrier Proteins,
pubmed-meshheading:9078267-Cell Differentiation,
pubmed-meshheading:9078267-Cell Line,
pubmed-meshheading:9078267-Fatty Acid-Binding Proteins,
pubmed-meshheading:9078267-Fatty Acids,
pubmed-meshheading:9078267-Gene Expression Regulation,
pubmed-meshheading:9078267-Half-Life,
pubmed-meshheading:9078267-Mice,
pubmed-meshheading:9078267-Myelin P2 Protein,
pubmed-meshheading:9078267-Neoplasm Proteins,
pubmed-meshheading:9078267-Nerve Tissue Proteins,
pubmed-meshheading:9078267-RNA, Messenger,
pubmed-meshheading:9078267-Stem Cells,
pubmed-meshheading:9078267-Transcription, Genetic
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pubmed:year |
1997
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pubmed:articleTitle |
Regulation by fatty acids of angiotensinogen gene expression in preadipose cells.
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pubmed:affiliation |
Centre de Biochimie du CNRS (UMR 6543), Université de Nice-Sophia Antipolis, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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