Linked Life Data

9077137

Source:http://linkedlifedata.com/resource/pubmed/id/9077137

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-4-15
pubmed:abstractText
The photoprotective properties of furocoumarin plus UVA-induced epidermal melanogenesis were assessed in hairless mice. The ear and dorsal surfaces were topically treated with 6,4,4'-trimethylangelicin (TMA), 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP) or psoralen and exposed to UVA for 12 consecutive week-days. The TMA treatment induced intense tanning whereas modest tanning was seen with the other compounds. Seven days after the last treatment, the mice were challenged with a DNA damaging dose of UV radiation. Single strand breaks (SSB) in epidermal DNA were assessed by alkaline elution. Photoprotection was assessed by comparing SSB in furocoumarin-treated mice with control mice (vehicle plus UVA and also no treatment). No photoprotection was seen, with any compound, in dorsal epidermis despite intense pigmentation induced by TMA. Modest photoprotection with all compounds was seen in ear epidermis that was independent of the level of pigmentation. These data show that induced melanogenesis is not always associated, with photoprotection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0031-8655
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
486-91
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Photoprotection by furocoumarin-induced melanogenesis against DNA photodamage in mouse epidermis in vivo.
pubmed:affiliation
Department of Photobiology, St. John's Institute of Dermatology, St. Thomas' Hospital, London, UK.
pubmed:publicationType
Journal Article