Linked Life Data

9071353

Source:http://linkedlifedata.com/resource/pubmed/id/9071353

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-4-10
pubmed:abstractText
Social separations can induce long-lasting increases in cortisol, whereas companionship can result in social buffering. Preliminary evidence from studies of squirrel monkeys suggests that social separation-induced hypersecretion of cortisol is initially driven by hypersecretion of ACTH. From 1-21 days postseparation, however, cortisol remains elevated above pre-separation controls, while ACTH levels are consistently reduced. Hypercortisolism is maintained despite reductions in ACTH, because adrenal responsiveness to ACTH is enhanced. Low circulating ACTH, in turn, is maintained by robust feedback mechanisms that apparently inhibit biosynthesis or release of pituitary ACTH. These findings are consistent with neuroendocrine interactions known or hypothesized to occur during major depressive disorders in humans and raise unique possibilities for comparative research in human and nonhuman primates.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
807
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
210-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Psychobiological consequences of social relationships.
pubmed:affiliation
Department of Psychology, University of Delaware, Newark 19716-2577, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review