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rdf:type |
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lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0007765,
umls-concept:C0009015,
umls-concept:C0017262,
umls-concept:C0019564,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0033684,
umls-concept:C0080347,
umls-concept:C0086418,
umls-concept:C0205314,
umls-concept:C0679058,
umls-concept:C0679622,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1547699,
umls-concept:C2700640
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pubmed:issue |
2
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pubmed:dateCreated |
1997-4-17
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pubmed:databankReference |
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pubmed:abstractText |
We identified a novel gene, kf-1, highly expressed in the normal cerebellum but not in the cerebral cortex, the expression of which could have been augmented in the cerebral cortex of a sporadic Alzheimer's disease patient. We cloned human and mouse entire kf-1 cDNAs encoding conserved 79 kDa proteins containing a zinc-binding RING-H2 finger motif at the carboxy-terminus as found in acetylcholine receptor-associated protein (RAPsyn). The 3'-untranslated regions are highly conserved between human and mouse as to constitute a common mRNA secondary structure. In situ hybridization analysis of mouse brain sections revealed strong kf-1 expression in the cerebellum and hippocampus. We propose that KF-1 is involved in membranous protein-sorting apparatus similarly to RAPsyn. We mapped the human kf-1 gene to 2p11.2.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-291X
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pubmed:author |
pubmed-author:AbeTT,
pubmed-author:Hashimoto-GotohTT,
pubmed-author:HosokawaYY,
pubmed-author:IbataYY,
pubmed-author:InazawaJJ,
pubmed-author:KikunoRR,
pubmed-author:KumaKK,
pubmed-author:MatsubaraKK,
pubmed-author:MiyataTT,
pubmed-author:MizunoTT,
pubmed-author:NakajimaKK,
pubmed-author:OhkuboKK,
pubmed-author:ShigeyoshiYY,
pubmed-author:TsujimuraAA,
pubmed-author:YasojimaKK
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|
pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
231
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
481-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9070305-Alzheimer Disease,
pubmed-meshheading:9070305-Amino Acid Sequence,
pubmed-meshheading:9070305-Animals,
pubmed-meshheading:9070305-Base Sequence,
pubmed-meshheading:9070305-Cerebellum,
pubmed-meshheading:9070305-Chromosome Mapping,
pubmed-meshheading:9070305-Chromosomes, Human, Pair 2,
pubmed-meshheading:9070305-Cloning, Molecular,
pubmed-meshheading:9070305-DNA, Complementary,
pubmed-meshheading:9070305-Female,
pubmed-meshheading:9070305-Gene Expression,
pubmed-meshheading:9070305-Hippocampus,
pubmed-meshheading:9070305-Humans,
pubmed-meshheading:9070305-Mice,
pubmed-meshheading:9070305-Molecular Sequence Data,
pubmed-meshheading:9070305-Nerve Tissue Proteins,
pubmed-meshheading:9070305-Nucleic Acid Conformation,
pubmed-meshheading:9070305-Protein Conformation,
pubmed-meshheading:9070305-RNA, Messenger,
pubmed-meshheading:9070305-Sequence Homology, Amino Acid,
pubmed-meshheading:9070305-Zinc Fingers
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pubmed:year |
1997
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pubmed:articleTitle |
Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus.
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pubmed:affiliation |
Department of Biochemistry and Molecular Genetics, Kyoto Prefectural University of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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