rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-4-4
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pubmed:abstractText |
Inhalational anesthetics interact with the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway in the central nervous system (CNS) and attenuate excitatory neurotransmitter-induced cGMP concentration. The site of anesthetic action on the NO-cGMP pathway in the CNS remains controversial. This study investigated the effect of inhalational anesthetics on N-methyl-D-aspartate (NMDA)-stimulated NO synthase activity and cyclic cGMP production in rat cerebellum slices.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Citrulline,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Halothane,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflurane,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0003-3022
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
689-98
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9066336-Anesthetics, Inhalation,
pubmed-meshheading:9066336-Animals,
pubmed-meshheading:9066336-Arginine,
pubmed-meshheading:9066336-Cerebellum,
pubmed-meshheading:9066336-Citrulline,
pubmed-meshheading:9066336-Cyclic GMP,
pubmed-meshheading:9066336-Drug Interactions,
pubmed-meshheading:9066336-Excitatory Amino Acid Agonists,
pubmed-meshheading:9066336-Halothane,
pubmed-meshheading:9066336-Isoflurane,
pubmed-meshheading:9066336-N-Methylaspartate,
pubmed-meshheading:9066336-Nitric Oxide,
pubmed-meshheading:9066336-Nitric Oxide Synthase,
pubmed-meshheading:9066336-Rats,
pubmed-meshheading:9066336-Rats, Sprague-Dawley,
pubmed-meshheading:9066336-Stimulation, Chemical,
pubmed-meshheading:9066336-Tritium
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pubmed:year |
1997
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pubmed:articleTitle |
Inhalational anesthetic effects on rat cerebellar nitric oxide and cyclic guanosine monophosphate production.
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pubmed:affiliation |
Department of Anesthesiology, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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