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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1997-3-27
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pubmed:abstractText |
The patient was initially diagnosed as having non-Hodgkin's lymphoma and was cured following treatment with prednisolone, vincristine, daunorubicin, 1-asparaginase, and cyclophosphamide. Seven years and two months later, he developed osteosarcoma in his right femur. He received chemotherapy consisting of methotrexate, carboplatin, etoposide, and ifosfamide and again obtained remission. After 2 years and 7 months, however, he was found to have pancytopenia with morphological abnormalities in the erythroid and myeloid series. Diagnosis of myelodysplastic syndrome (MDS) was made. Cytogenetic analysis of bone marrow cells revealed -5 and -7, which is typical for secondary MDS. This is a rare case of third malignancy presumably caused by alkylating agents.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0939-5555
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9063380-Adolescent,
pubmed-meshheading:9063380-Antineoplastic Agents, Alkylating,
pubmed-meshheading:9063380-Chromosome Aberrations,
pubmed-meshheading:9063380-Chromosome Disorders,
pubmed-meshheading:9063380-Chromosomes, Human, Pair 5,
pubmed-meshheading:9063380-Chromosomes, Human, Pair 7,
pubmed-meshheading:9063380-Humans,
pubmed-meshheading:9063380-Karyotyping,
pubmed-meshheading:9063380-Lymphoma, Non-Hodgkin,
pubmed-meshheading:9063380-Male,
pubmed-meshheading:9063380-Myelodysplastic Syndromes,
pubmed-meshheading:9063380-Osteosarcoma
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pubmed:year |
1997
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pubmed:articleTitle |
Myelodysplastic syndrome presenting as third malignancy after non-Hodgkin's lymphoma and osteosarcoma.
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pubmed:affiliation |
Department of Pediatrics, Kyoto University, Japan.
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pubmed:publicationType |
Journal Article,
Case Reports
|