|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0000768,
umls-concept:C0021853,
umls-concept:C0022688,
umls-concept:C0024264,
umls-concept:C0026809,
umls-concept:C0034819,
umls-concept:C0205100,
umls-concept:C0330390,
umls-concept:C0337112,
umls-concept:C1512942,
umls-concept:C1524075
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1997-3-13
|
|
pubmed:abstractText |
The interleukin-2 receptor beta chain (IL-2R beta) is expressed on a variety of hematopoietic cell types, including natural killer (NK) cells and nonconventional T lymphocyte subsets such as intestinal intraepithelial lymphocytes (IEL). However, the importance of IL-2R beta-mediated signaling in the growth and development of these cells has yet to be clearly established. We have investigated IEL and NK cells in mice deficient for IL-2R beta and describe here striking defects in the development of these cells. IL-2R beta-/- mice exhibited an abnormal IEL cell population, characterized by a dramatic reduction in T cell receptor alpha beta CD8 alpha alpha and T cell receptor gamma delta lymphocytes. This selective decrease indicates that IEL can be classified into those whose development and/or differentiation is dependent on IL-2R beta function and those for which IL-2R beta-mediated signaling is not essential. NK cell development was also found to be disrupted in IL-2R beta-deficient mice, characterized by a reduction in NK1.1+CD3- cells in the peripheral circulation and an absence of NK cytotoxic activity in vitro. The dependence of NK cells and certain subclasses of IEL cells on IL-2R beta expression points to an essential role for signaling through this receptor, presumably by IL-2 and/or IL-15, in the development of lymphocyte-subsets of extrathymic origin.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-1350462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-1476600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-1506685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-1532536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-1590986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-1707657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-1968230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-1975820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-2110244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-2319807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-2683611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-2787381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-7504051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-7519241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-7523571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-7546383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-7584142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-7641685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-7770771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-7831294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-7931056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8011290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8046340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8046341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8178155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8235625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8258353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8287493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8350049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8380826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8397768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8462096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8462103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8476561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8476574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8482578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8605934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8691145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8692964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8760786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8814274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053450-8906800
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0022-1007
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
3
|
|
pubmed:volume |
185
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
499-505
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:9053450-Animals,
pubmed-meshheading:9053450-Cytotoxicity, Immunologic,
pubmed-meshheading:9053450-Interleukin-15,
pubmed-meshheading:9053450-Interleukin-2,
pubmed-meshheading:9053450-Intestines,
pubmed-meshheading:9053450-Killer Cells, Natural,
pubmed-meshheading:9053450-Lymphocytes,
pubmed-meshheading:9053450-Mice,
pubmed-meshheading:9053450-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:9053450-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:9053450-Receptors, Interleukin-2
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain.
|
|
pubmed:affiliation |
Amgen Institute, Toronto, Ontario, Canada.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
