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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
1997-3-13
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pubmed:abstractText |
Fluorescence in situ hybridization (FISH) analysis of metaphase and decondensed free chromatin fibers from Adriamycin (ADR)-sensitive and ADR-resistant murine cells demonstrated a close juxtaposition of topoisomerase II alpha (Top2a) and retinoic acid receptor alpha (Rara) genes in adjacent chromatin in the drug-resistant cells, and a close but separate genetic proximity in normal murine chromatin. This provides physical evidence that the chromosome 11 allelic rearrangement resulting in a chimeric truncated Top2a/Rara transcript in the ADR-resistant cells is due to a novel fusion of the Topo2a and Rara genes. This is the first description of a Rara gene disruption in cells selected for antineoplastic drug resistance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Topoisomerases, Type II,
http://linkedlifedata.com/resource/pubmed/chemical/DNA topoisomerase II alpha,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid
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pubmed:status |
MEDLINE
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pubmed:issn |
0301-0171
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
164-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9040785-Alleles,
pubmed-meshheading:9040785-Animals,
pubmed-meshheading:9040785-Antibiotics, Antineoplastic,
pubmed-meshheading:9040785-Antigens, Neoplasm,
pubmed-meshheading:9040785-Cells, Cultured,
pubmed-meshheading:9040785-Chromosome Aberrations,
pubmed-meshheading:9040785-DNA Topoisomerases, Type II,
pubmed-meshheading:9040785-DNA-Binding Proteins,
pubmed-meshheading:9040785-Doxorubicin,
pubmed-meshheading:9040785-Drug Resistance, Neoplasm,
pubmed-meshheading:9040785-In Situ Hybridization, Fluorescence,
pubmed-meshheading:9040785-Isoenzymes,
pubmed-meshheading:9040785-Leukemia P388,
pubmed-meshheading:9040785-Mice,
pubmed-meshheading:9040785-Receptors, Retinoic Acid,
pubmed-meshheading:9040785-Recombination, Genetic,
pubmed-meshheading:9040785-Stem Cells,
pubmed-meshheading:9040785-Tumor Cells, Cultured
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pubmed:year |
1996
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pubmed:articleTitle |
Allelic fusion of DNA topoisomerase II alpha and retinoic acid receptor alpha genes in adriamycin-resistant p388 murine leukemia revealed by fluorescence in situ hybridization.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, University of Toronto, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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