|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1997-3-27
|
|
pubmed:abstractText |
B cells play an important role in the allergic response by producing allergen-specific Igs as well as by serving as antigen-presenting cells. We studied the involvement of B cells in the development of responses in a murine model of allergic airway sensitization. Normal and B cell-deficient (muMt-/-) B10.BR mice were sensitized via the airways to ovalbumin; Ig production, cytokine elaboration from local lymph node cells, development of airway hyperresponsiveness, and histological changes in the airways were evaluated. Both strains of mice had increased production of T helper 2-like cytokines and developed an accumulation of eosinophils in the bronchial tissue after airway sensitization. However, only wild-type mice produced allergen-specific antibodies and exhibited altered airway function. B cell-deficient mice reconstituted with anti-ovalbumin IgE during the course of sensitization developed increases in airway responsiveness. These results indicated that neither B cells nor IgE were necessary for the induction of a T helper 2-type cytokine response or eosinophil infiltration of the airways after allergic sensitization but that IgE was required as a second signal for the development of airway hyperresponsiveness in this model of airway sensitization.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-1541669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-1607548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-1744589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-1793528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-1891008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-1901381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-2151403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-2215562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-2529541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-2911321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-2952725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-2966762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-3100626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-7561694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-7769121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-7812166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8041705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8093895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8105735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8133062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8179909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8254203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8258338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8351517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8418407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8423213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8436906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8459211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8551212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8551213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8570666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8617871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8618887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8642325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8642326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8666888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8666892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9037056-8666929
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
18
|
|
pubmed:volume |
94
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1350-5
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:9037056-Animals,
pubmed-meshheading:9037056-Antibody Specificity,
pubmed-meshheading:9037056-B-Lymphocytes,
pubmed-meshheading:9037056-Cytokines,
pubmed-meshheading:9037056-Eosinophils,
pubmed-meshheading:9037056-Female,
pubmed-meshheading:9037056-Immunization,
pubmed-meshheading:9037056-Immunoglobulin E,
pubmed-meshheading:9037056-Immunoglobulin G,
pubmed-meshheading:9037056-Lung,
pubmed-meshheading:9037056-Lymph Nodes,
pubmed-meshheading:9037056-Lymphocyte Activation,
pubmed-meshheading:9037056-Lymphocytes,
pubmed-meshheading:9037056-Mice,
pubmed-meshheading:9037056-Mice, Mutant Strains,
pubmed-meshheading:9037056-Ovalbumin,
pubmed-meshheading:9037056-Respiratory Hypersensitivity,
pubmed-meshheading:9037056-T-Lymphocytes,
pubmed-meshheading:9037056-Trachea
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice.
|
|
pubmed:affiliation |
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
