| pubmed-article:9033279 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9033279 | lifeskim:mentions | umls-concept:C0020094 | lld:lifeskim |
| pubmed-article:9033279 | lifeskim:mentions | umls-concept:C0024314 | lld:lifeskim |
| pubmed-article:9033279 | lifeskim:mentions | umls-concept:C0079773 | lld:lifeskim |
| pubmed-article:9033279 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:9033279 | lifeskim:mentions | umls-concept:C1158478 | lld:lifeskim |
| pubmed-article:9033279 | lifeskim:mentions | umls-concept:C1705422 | lld:lifeskim |
| pubmed-article:9033279 | lifeskim:mentions | umls-concept:C0332125 | lld:lifeskim |
| pubmed-article:9033279 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9033279 | pubmed:dateCreated | 1997-3-18 | lld:pubmed |
| pubmed-article:9033279 | pubmed:abstractText | Several recent studies have reported detection of HTLV-I genetic sequences in patients with cutaneous T-cell lymphoma (CTCL) including mycosis fungoides and Sezary syndrome. The purpose of this study was to determine whether HTLV-I was detectable in lesional tissues of patients suffering from diseases known to be associated with CTCL. Thirty-five cases were obtained from diverse geographical locations including Ohio, California, Switzerland, and Japan. Six of them had concurrent CTCL. Cases were analyzed using a combination of genomic polymerase chain reaction (PCR)/ Southern blot, dot blot, and Southern blot analyses. All assays were specific for HTLV-I provirus. Sensitivity ranged from approximately 10(-6) for PCR-based studies to 10(-2) for unamplified genomic blotting. Lesional DNA from patients with lymphomatoid papulosis (fourteen cases), Hodgkin's disease (twelve cases), and CD30+ large-cell lymphoma (nine cases) was tested for the HTLV-I proviral pX region using a genomic PCR assay followed by confirmatory Southern blot analysis with a nested oligonucleotide pX probe. All cases were uniformly negative. All of the Hodgkin's disease cases, eight of the large-cell lymphoma cases, and six of the lymphomatoid papulosis cases were then subjected to dot blot analysis of genomic DNA using a full-length HTLV-I proviral DNA probe that spans all regions of the HTLV-I genome. Again, all cases were negative. Finally, eleven of the Hodgkin's disease cases were also subjected to Southern blot analysis of EcoRI-digested genomic DNA using the same full-length HTLV-I probe. Once again, all cases were negative. These findings indicated that, despite utilization of a variety of sensitive and specific molecular biological methods, HTLV-I genetic sequences were not detectable in patients with CTCL-associated lymphoproliferative disorders. These results strongly suggest that the HTLV-I retrovirus is not involved in the pathogenesis of these diseases. | lld:pubmed |
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| pubmed-article:9033279 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9033279 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9033279 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9033279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9033279 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9033279 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9033279 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:9033279 | pubmed:author | pubmed-author:TakeshitaMM | lld:pubmed |
| pubmed-article:9033279 | pubmed:author | pubmed-author:KikuchiMM | lld:pubmed |
| pubmed-article:9033279 | pubmed:author | pubmed-author:AVISK EKE | lld:pubmed |
| pubmed-article:9033279 | pubmed:author | pubmed-author:WoodG SGS | lld:pubmed |
| pubmed-article:9033279 | pubmed:author | pubmed-author:BoniRR | lld:pubmed |
| pubmed-article:9033279 | pubmed:author | pubmed-author:DummerRR | lld:pubmed |
| pubmed-article:9033279 | pubmed:author | pubmed-author:SchafferJ MJM | lld:pubmed |
| pubmed-article:9033279 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9033279 | pubmed:volume | 150 | lld:pubmed |
| pubmed-article:9033279 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9033279 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9033279 | pubmed:pagination | 667-73 | lld:pubmed |
| pubmed-article:9033279 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
| pubmed-article:9033279 | pubmed:meshHeading | pubmed-meshheading:9033279-... | lld:pubmed |
| pubmed-article:9033279 | pubmed:meshHeading | pubmed-meshheading:9033279-... | lld:pubmed |
| pubmed-article:9033279 | pubmed:meshHeading | pubmed-meshheading:9033279-... | lld:pubmed |
| pubmed-article:9033279 | pubmed:meshHeading | pubmed-meshheading:9033279-... | lld:pubmed |
| pubmed-article:9033279 | pubmed:meshHeading | pubmed-meshheading:9033279-... | lld:pubmed |
| pubmed-article:9033279 | pubmed:meshHeading | pubmed-meshheading:9033279-... | lld:pubmed |
| pubmed-article:9033279 | pubmed:meshHeading | pubmed-meshheading:9033279-... | lld:pubmed |
| pubmed-article:9033279 | pubmed:meshHeading | pubmed-meshheading:9033279-... | lld:pubmed |
| pubmed-article:9033279 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9033279 | pubmed:articleTitle | No evidence of HTLV-I proviral integration in lymphoproliferative disorders associated with cutaneous T-cell lymphoma. | lld:pubmed |
| pubmed-article:9033279 | pubmed:affiliation | Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA. | lld:pubmed |
| pubmed-article:9033279 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9033279 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9033279 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
