Linked Life Data

9025871

Source:http://linkedlifedata.com/resource/pubmed/id/9025871

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-3-6
pubmed:abstractText
Cerebrospinal fluid (CSF) samples from four infants 3 days to 4 months of age with a history of prematurity or birth trauma were found to contain clusters of immature cells. These cells were arranged in groups or syncytia, sometimes with nuclear molding, and were cytologically characterized by scant basophilic cytoplasm, nuclei with fine nuclear chromatin, and small nucleoli. The picture simulated the appearance of metastatic tumor admixed with hemosiderin-laden macrophages, erythrocytes, and leukocytes. Because of the low numbers of cells or aggregates present in CSF samples and the relatively small quantity of CSF obtained, immunohistochemical and flow cytometric evaluations were not performed. Prior studies have designated these immature cells as undifferentiated leptomeningeal cells or cells from the subependymal germinal matrix and have associated their presence with intraventricular hemorrhage (IVH) in premature newborns. Three of our patients had a history of prematurity; the fourth patient suffered a traumatic birth but was not premature. In long-term follow-up, the patients have not shown progression of neurologic deficits or evidence of malignancy. Thus, it is important to recognize that in infants with a history of IVH, subarachnoid hemorrhage, or ventricular drainage devices, the presence of tumorlike clumps of cells associated with hemosiderin-laden macrophages most likely does not represent metastatic tumor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1077-1042
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
721-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Tumorlike clusters of immature cells in cerebrospinal fluid of infants.
pubmed:affiliation
Department of Pathology, University of Pittsburgh, PA 15213, USA.
pubmed:publicationType
Journal Article, Case Reports