|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1997-2-24
|
|
pubmed:abstractText |
Thrombospondin-1 (TSP) is a 430-kd glycoprotein that is an important component of the extracellular matrix and is known to be a potent inhibitor of angiogenesis (i.e., formation of new blood vessels) both in vitro and in vivo. Several reports suggest that TSP possesses tumor suppressor function, possibly through its ability to inhibit tumor neovascularization. It has recently been shown that TSP expression is enhanced by the product of the p53 gene (also known as TP53).
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0027-8874
|
|
pubmed:author |
pubmed-author:BochnerB HBH,
pubmed-author:CoteR JRJ,
pubmed-author:DunnMM,
pubmed-author:EsrigDD,
pubmed-author:GinsbergD ADA,
pubmed-author:GroshenSS,
pubmed-author:GrossfeldG DGD,
pubmed-author:NicholsP WPW,
pubmed-author:SkinnerD GDG,
pubmed-author:SteinJ PJP,
pubmed-author:TaylorC RCR
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
89
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
219-27
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:9017002-Adult,
pubmed-meshheading:9017002-Aged,
pubmed-meshheading:9017002-Aged, 80 and over,
pubmed-meshheading:9017002-Carcinoma, Transitional Cell,
pubmed-meshheading:9017002-Cell Adhesion Molecules,
pubmed-meshheading:9017002-Disease Progression,
pubmed-meshheading:9017002-Female,
pubmed-meshheading:9017002-Follow-Up Studies,
pubmed-meshheading:9017002-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:9017002-Humans,
pubmed-meshheading:9017002-Lymphatic Metastasis,
pubmed-meshheading:9017002-Male,
pubmed-meshheading:9017002-Membrane Glycoproteins,
pubmed-meshheading:9017002-Middle Aged,
pubmed-meshheading:9017002-Neoplasm Staging,
pubmed-meshheading:9017002-Neovascularization, Pathologic,
pubmed-meshheading:9017002-Recurrence,
pubmed-meshheading:9017002-Survival Analysis,
pubmed-meshheading:9017002-Thrombospondins,
pubmed-meshheading:9017002-Tumor Suppressor Protein p53,
pubmed-meshheading:9017002-Urinary Bladder Neoplasms
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Thrombospondin-1 expression in bladder cancer: association with p53 alterations, tumor angiogenesis, and tumor progression.
|
|
pubmed:affiliation |
Department of Pathology, University of Southern California School of Medicine, Los Angeles 90033, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
