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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-4-8
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pubmed:abstractText |
Although low plasma vitamin A levels are associated with increased mortality and higher vertical transmission during human immunodeficiency virus (HIV) infection, it is unknown whether plasma low vitamin A levels are a marker for circulating HIV load. We conducted a cross-sectional study within a prospective cohort study of injection drug users in order to evaluate the relationship between plasma vitamin A levels and HIV viral load. Plasma vitamin A level was measured by high-performance liquid chromatography. Infectious viral load was measured by quantitative microculture of serial fivefold dilutions of 10(6) peripheral blood mononuclear cells. A total of 284 HIV-infected adults (79 women, 205 men) were studied. Plasma vitamin A levels consistent with deficiency were found in 28.9% of adults. A total of 38.0% of women and 25.3% of men had vitamin A deficiency (P < 0.04). The median infectious viral load for the entire study population was 8 infectious units per million cells. No significant relationship between plasma vitamin A levels and infectious viral load was observed in these injection drug users. This study suggests that there is no correlation between HIV viral load and plasma vitamin A levels in injection drug users, and these variables may represent independent risk factors during HIV infection. HIV-infected adult women appear to be at higher risk of developing vitamin A deficiency.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-1372988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-1503689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-1560208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-3172345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-6968909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-711370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-7594703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-7622874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-7625499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-7636537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-7708773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-7718183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-7751694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-7834403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-7901636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-7904452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-7911919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-8119938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-8195386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-8379807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-8524896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9008289-8645848
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1071-412X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9008289-Adult,
pubmed-meshheading:9008289-Biological Markers,
pubmed-meshheading:9008289-Cohort Studies,
pubmed-meshheading:9008289-Cross-Sectional Studies,
pubmed-meshheading:9008289-Female,
pubmed-meshheading:9008289-HIV Infections,
pubmed-meshheading:9008289-Humans,
pubmed-meshheading:9008289-Male,
pubmed-meshheading:9008289-Substance Abuse, Intravenous,
pubmed-meshheading:9008289-Viral Load,
pubmed-meshheading:9008289-Vitamin A
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pubmed:year |
1997
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pubmed:articleTitle |
Vitamin A levels and human immunodeficiency virus load in injection drug users.
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pubmed:affiliation |
Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. rdsemba@welchlink.welch.jhu.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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