Linked Life Data

9008224

Source:http://linkedlifedata.com/resource/pubmed/id/9008224

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-2-13
pubmed:abstractText
Many studies report that sunscreens effective against UVR-induced inflammation afford poor protection against immunosuppression. We have studied the relationship between photoprotection of inflammation and immunosuppression with monochromatic UVB (Philips TL01 tubes, lambda max = 311 nm) to remove possible confounding effects of differences in end point action spectra. Dose-response curves for edema and systemic suppression of contact hypersensitivity (CHS) in HRA.HRII-c/+/Skh mice showed that suppression of CHS was more sensitive to UVB irradiation by a factor of 2. The UVB dose-response curve for murine edema was similar to that for human erythema, with threshold doses of 773 mJ x cm(-2) and 632 mJ x cm(-2), respectively. The protection afforded by two UVB filters, octyl dimethyl para-aminobenzoic acid and 2-ethylhexyl-4'-methoxycinnamate, prepared in an identical vehicle, each with the same optical density at 311 nm, was tested in mice. We applied sunscreen to all exposed skin or to transpore tape above the irradiation cages, prior to exposure with 2.8 minimal edema doses. Topical or tape application of both sunscreens protected totally against edema but only partially against immunosuppression, with no significant difference in protection between the two application techniques (p > 0.4). A sunscreen protection factor of 4 in vivo was determined for 2-ethylhexyl-4'-methoxycinnamate for both edema and immunosuppression. Failure of the sunscreens to protect completely against immunosuppression was due to the ability of subedemal doses of UVB to induce substantial immunosuppression and not, as previously suggested, to any skin interaction.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-202X
pubmed:author
pubmed:issnType
Print
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Sunscreens offer the same UVB protection factors for inflammation and immunosuppression in the mouse.
pubmed:affiliation
Department of Photobiology, St. John's Institute of Dermatology, United Medical and Dental Schools of Guy's and St Thomas's Hospital, University of London, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't