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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-2-7
|
| pubmed:abstractText |
The DNA sequences of a novel human gamma-herpesvirus type 8 (HHV-8) have recently been detected in Kaposi's sarcoma (KS) lesions obtained from different populations in whom this neoplasm occurs, suggesting that this virus may be implicated in the etiology and/or pathogenesis of KS. To study the distribution and possible means of transmission of the putative viral agent, specimens of KS skin lesions, matched uninvolved skin, peripheral blood mononuclear cells (PB-MCs), and semen were collected from 12 HIV-positive homosexual men with acquired immune deficiency syndrome (AIDS)-related KS (AIDS-KS) and 2 human immunodeficiency virus (HIV)-negative homosexual men with KS. HHV-8 virus DNA was detected by polymerase chain reaction (PCR) studies in all 14 of these KS specimens and in 6 of 14 biopsies of normal-appearing skin distant from any KS lesions including 1 uninvolved skin specimen from an HIV-negative homosexual male with KS. In addition, 3 of 12 PBMC samples and 3 of 12 semen samples from the AIDS-KS patients were positive for HHV-8. The DNA sequences of HHV-8 were not detected in the matched semen and PBMC specimens obtained from 2 HIV-negative homosexual men with KS, 4 HIV-positive homosexual patients without KS, 2 HIV-seronegative healthy homosexual men, 5 HIV-positive heterosexual male intravenous drug users, or 5 healthy HIV-negative heterosexual donors. Using PCR in situ, positive signals for HHV-8 were demonstrated in the B lymphocyte subsets of PBMCs and/or in spermatozoa and mononuclear cells in the semen from some of the PCR-positive specimens from the AIDS-KS patients examined. These data show that HHV-8 is present in and could possibly be transmitted via semen and/or blood from some homosexual men with AIDS-KS.
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| pubmed:grant | |
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-1457502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-1661072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-179178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-1967430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-2227421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-3349645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-4672946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-7489408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-7500753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-7554505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-7674745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-7700310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-7723504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-7725108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-7891487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-7891488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-7997879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006331-8669460
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0002-9440
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
150
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
147-53
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:9006331-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:9006331-DNA, Viral,
pubmed-meshheading:9006331-Herpesvirus 8, Human,
pubmed-meshheading:9006331-Humans,
pubmed-meshheading:9006331-In Situ Hybridization,
pubmed-meshheading:9006331-Male,
pubmed-meshheading:9006331-Polymerase Chain Reaction,
pubmed-meshheading:9006331-Sarcoma, Kaposi,
pubmed-meshheading:9006331-Semen,
pubmed-meshheading:9006331-Skin Neoplasms
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Detection of the herpesvirus-like DNA sequences in matched specimens of semen and blood from patients with AIDS-related Kaposi's sarcoma by polymerase chain reaction in situ hybridization.
|
| pubmed:affiliation |
Department of Dermatology, New York University Medical Center 10016, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|