Linked Life Data

9005449

Source:http://linkedlifedata.com/resource/pubmed/id/9005449

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-1-30
pubmed:abstractText
A 70% EtOH extract of Clerodendrum mandarinorum root bark was assessed for CNS activity against 18 radioligand receptor binding assays. The results showed that the extract was able to bind to opiate, adenosine-1, alpha 2-adrenergic, 5HT-1, 5HT-2, dopamine-2, histamine-1, GABA(A), and GABA(B) receptors. Fourteen compounds were isolated and identified by El-MS, 1H-NMR and 13C-NMR spectra as known triterpenoids (friedelanone, lupeol, betulinic acid), steroids (24S-stigmata-5,25-dien-3 beta-ol,22E,24S-stigmata-5,22,25-trien-3 beta-ol), flavonoids (cirsimaritin, cirsimaritin-4'-glucoside, quercetin-3-methyl ether), tetra-hydro-alpha-pyrone and saccharides (sucrose, alpha-D- and beta-D-glucopyranose, ethyl-alpha-D-glucopyranoside, 2-ethyl-beta-D-fructofuranoside). The isolated compounds were assessed for activity by the radioligand receptor binding assays. Betulinic acid and ethyl-alpha-D-glucopyranoside showed weak activities against sulphonylureas (IC50 = 7.5 microM) and muscarinic receptors (IC50 = 5.5 microM), respectively. Cirsimaritin-4'-glucoside was weakly active in the adenosine-1 binding assay (IC50 = 3.0 microM), whereas seven structurally related flavonoids, not isolated from C.mandarinorum, were inactive.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0032-0943
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
393-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Chemical and biological investigation of the root bark of Clerodendrum mandarinorum.
pubmed:affiliation
Department of Pharmacy, The Chinese University of Hong Kong, Shatin.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't