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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-2-19
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pubmed:abstractText |
It has been suggested that antibodies against GM1 are involved in the pathogenesis of the Guillain-Barré syndrome (GBS). Recently, we have developed a standardized ELISA assay for anti-GM1 antibodies of IgM type well-suited for longitudinal patient studies. The relationship between serum antibodies against GM1 and Campylobacter jejuni was investigated in patients with GBS and in patients with C. jejuni infection. Patients with a short-lasting anti-GM1 elevation had a fast recovery, whereas patients with slow recovery had a long-lasting anti-GM1 elevation. A linear relationship was found between significant clinical recovery and the time until the anti-GM1 peak was halved (R = 0.9, p < 0.01). The absolute level of anti-GM1 did not predict the length of the recovery nor was the level of anti-GM1 related to the clinical disability at its nadir. Our data indicate that monitoring of the IgM anti-GM1 level can predict clinical recovery in GBS patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-66
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9003245-Adolescent,
pubmed-meshheading:9003245-Adult,
pubmed-meshheading:9003245-Aged,
pubmed-meshheading:9003245-Aged, 80 and over,
pubmed-meshheading:9003245-Antibodies, Bacterial,
pubmed-meshheading:9003245-Antibody Specificity,
pubmed-meshheading:9003245-Autoantibodies,
pubmed-meshheading:9003245-Campylobacter Infections,
pubmed-meshheading:9003245-Campylobacter jejuni,
pubmed-meshheading:9003245-Disease Progression,
pubmed-meshheading:9003245-Female,
pubmed-meshheading:9003245-G(M1) Ganglioside,
pubmed-meshheading:9003245-Humans,
pubmed-meshheading:9003245-Immunoglobulin G,
pubmed-meshheading:9003245-Immunoglobulin M,
pubmed-meshheading:9003245-Immunoglobulins, Intravenous,
pubmed-meshheading:9003245-Male,
pubmed-meshheading:9003245-Middle Aged,
pubmed-meshheading:9003245-Polyradiculoneuropathy,
pubmed-meshheading:9003245-Predictive Value of Tests
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pubmed:year |
1997
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pubmed:articleTitle |
IgM anti-GM1 antibodies in the Guillain-Barré syndrome: a serological predictor of the clinical course.
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pubmed:affiliation |
Department of Neurology, Aarhus University Hospital, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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