Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5298
pubmed:dateCreated
1997-1-30
pubmed:abstractText
Familial combined hyperlipidemia (FCHL) is a common inherited lipid disorder, affecting 1 to 2 percent of the population in Westernized societies. Individuals with FCHL have large quantities of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) and develop premature coronary heart disease. A mouse model displaying some of the features of FCHL was created by crossing mice carrying the human apolipoprotein C-III (APOC3) transgene with mice deficient in the LDL receptor. A synergistic interaction between the apolipoprotein C-III and the LDL receptor defects produced large quantities of VLDL and LDL and enhanced the development of atherosclerosis. This mouse model may provide clues to the origin of human FCHL.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein C-III, http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B, http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins C, http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E, http://linkedlifedata.com/resource/pubmed/chemical/CETP protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL, http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL, http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, VLDL, http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol Ester Transfer Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, VLDL, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL, http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides, http://linkedlifedata.com/resource/pubmed/chemical/lipoprotein cholesterol
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
275
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:8994037-Animals, pubmed-meshheading:8994037-Apolipoprotein C-III, pubmed-meshheading:8994037-Apolipoproteins B, pubmed-meshheading:8994037-Apolipoproteins C, pubmed-meshheading:8994037-Apolipoproteins E, pubmed-meshheading:8994037-Arteriosclerosis, pubmed-meshheading:8994037-Carrier Proteins, pubmed-meshheading:8994037-Cholesterol, pubmed-meshheading:8994037-Cholesterol, HDL, pubmed-meshheading:8994037-Cholesterol, LDL, pubmed-meshheading:8994037-Cholesterol, VLDL, pubmed-meshheading:8994037-Cholesterol Ester Transfer Proteins, pubmed-meshheading:8994037-Diet, pubmed-meshheading:8994037-Disease Models, Animal, pubmed-meshheading:8994037-Disease Susceptibility, pubmed-meshheading:8994037-Female, pubmed-meshheading:8994037-Glycoproteins, pubmed-meshheading:8994037-Humans, pubmed-meshheading:8994037-Hyperlipidemia, Familial Combined, pubmed-meshheading:8994037-Hyperlipoproteinemia Type IV, pubmed-meshheading:8994037-Lipoproteins, pubmed-meshheading:8994037-Lipoproteins, VLDL, pubmed-meshheading:8994037-Male, pubmed-meshheading:8994037-Mice, pubmed-meshheading:8994037-Mice, Inbred C57BL, pubmed-meshheading:8994037-Mice, Transgenic, pubmed-meshheading:8994037-Receptors, LDL, pubmed-meshheading:8994037-Transgenes, pubmed-meshheading:8994037-Triglycerides
pubmed:year
1997
pubmed:articleTitle
A mouse model with features of familial combined hyperlipidemia.
pubmed:affiliation
Department of Medicine, Columbia University, 630 West 168 Street, New York, NY 10032, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.