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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-3-19
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pubmed:abstractText |
Insulin-like growth factor type I (IGF-I) has been used as a treatment for cachexia in adults with AIDS and has been reported to show inhibitory activity against HIV-1IIIB in cord blood mononuclear cells (CBMCs) in vitro at low-concentration (1%) fetal bovine serum (FCS). We evaluated the effect of IGF-I on MN, IIIB, and BaL strains, as well as on a patient isolate of HIV-1 in CBMCs and adult peripheral blood mononuclear cells (PBMCs). IGF-I failed to show any inhibitory effect on HIV replication in CBMCs or adult PBMCs under various culture conditions. In contrast to an earlier report of an antiviral effect, IGF-I augmented HIV-1 replication in PHA-stimulated PBMCs maintained in a low concentration of FCS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0889-2229
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-10
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8989433-Adult,
pubmed-meshheading:8989433-Antibodies, Monoclonal,
pubmed-meshheading:8989433-Cell Division,
pubmed-meshheading:8989433-Cell Survival,
pubmed-meshheading:8989433-Cells, Cultured,
pubmed-meshheading:8989433-HIV Core Protein p24,
pubmed-meshheading:8989433-HIV-1,
pubmed-meshheading:8989433-Humans,
pubmed-meshheading:8989433-Immunophenotyping,
pubmed-meshheading:8989433-Insulin-Like Growth Factor I,
pubmed-meshheading:8989433-Leukocytes, Mononuclear,
pubmed-meshheading:8989433-Lymphocyte Activation,
pubmed-meshheading:8989433-Receptor, IGF Type 1,
pubmed-meshheading:8989433-Umbilical Cord,
pubmed-meshheading:8989433-Virus Replication
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pubmed:year |
1997
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pubmed:articleTitle |
Failure of insulin-like growth factor type I to suppress HIV type 1 in adult or umbilical cord mononuclear blood cells.
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pubmed:affiliation |
Department of Molecular Microbiology and Immunology, School of Public Health an d Hygiene, Johns Hopkins University, Baltimore, Maryland 21205, USA.
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pubmed:publicationType |
Journal Article
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