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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1997-2-13
|
| pubmed:abstractText |
Many cytokines (growth-factor proteins) are constructed from a common four-helix bundle structural framework. Rapid advances have been made in relating the structure and function of a growing number of four-helix bundle cytokines. This understanding opens the way to design de novo mimetics through such strategies as cytokine hybrids, structure-excerpted scaffolds and contact residue topology mimics. These may provide leads for agonists and antagonists of cell growth and differentiation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
B
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0167-7799
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
369-75
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8987635-Animals,
pubmed-meshheading:8987635-Binding Sites,
pubmed-meshheading:8987635-Biotechnology,
pubmed-meshheading:8987635-Cytokines,
pubmed-meshheading:8987635-Drug Design,
pubmed-meshheading:8987635-Humans,
pubmed-meshheading:8987635-Molecular Structure,
pubmed-meshheading:8987635-Protein Conformation,
pubmed-meshheading:8987635-Receptors, Cytokine
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Identifying structure-function relationships in four-helix bundle cytokines: towards de novo mimetics design.
|
| pubmed:affiliation |
Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia 19104-6100, USA. chaiken@mail.med.upenn.edv
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|