Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-1-31
pubmed:databankReference
pubmed:abstractText
Human immunodeficiency virus type 1 (HIV-1) replication depends on the posttranscriptional regulation by the viral Rev protein and can be replaced with the posttranscriptional RNA control element (CTE) of the type D simian retroviruses. We have identified a sequence which shares only nucleotide sequences of the internal loops and secondary structure with the CTE and which is part of a novel murine intracisternal-A particle (IAP) retroelement, inserted within the transcribed mouse osteocalcin-related gene. This sequence, named CTE(IAP), can replace the Rev-mediated regulation of HIV-1, hence it is a posttranscriptional regulatory element. Related elements have been identified in other IAPs. These results suggest that insertional mutagenesis can affect gene expression by providing a functional posttranscriptional control element. The CTE(IAP) and CTEs of the type D simian retroviruses represent a novel class of RNA elements characterized by unique sequences within the internal loops which are predicted to represent the interaction site with cellular factor(s). These findings suggest that such elements may be involved in posttranscriptional regulation of cellular mRNAs.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-1406488, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-1545819, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-1725960, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-1727477, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-1827422, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-1920613, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-2055466, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-2170981, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-2217190, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-2335812, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-2482226, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-2562124, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-2686839, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-2704072, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-2736624, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-2784194, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-2784208, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-2834826, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-2835230, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-3006247, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-3016298, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-3025015, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-3035544, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-3146900, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-3174625, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-3412474, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-3638988, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-7624135, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-7637007, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-7707519, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-7760794, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-7891679, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-7966585, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-8108397, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-8116254, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-8151782, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-8243336, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-8246965, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-8288580, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-8524879, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-8648719, http://linkedlifedata.com/resource/pubmed/commentcorrection/8985327-8709222
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-101
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:8985327-Humans, pubmed-meshheading:8985327-Animals, pubmed-meshheading:8985327-Mice, pubmed-meshheading:8985327-RNA, pubmed-meshheading:8985327-Base Sequence, pubmed-meshheading:8985327-Amino Acid Sequence, pubmed-meshheading:8985327-Molecular Sequence Data, pubmed-meshheading:8985327-Cell Line, Transformed, pubmed-meshheading:8985327-Gene Expression Regulation, Viral, pubmed-meshheading:8985327-Databases, Factual, pubmed-meshheading:8985327-Regulatory Sequences, Nucleic Acid, pubmed-meshheading:8985327-Sequence Homology, Nucleic Acid, pubmed-meshheading:8985327-RNA Processing, Post-Transcriptional, pubmed-meshheading:8985327-Osteocalcin, pubmed-meshheading:8985327-Genes, Intracisternal A-Particle, pubmed-meshheading:8985327-HIV-1, pubmed-meshheading:8985327-Gene Products, rev
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