Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-1-23
pubmed:abstractText
Rhodamine B-labelled poly (DL-lactide-co-glycolide) (PLAGA) microspheres of 2 different sizes, 1-5 microns and 5-10 microns, were administered as a single dose (1.44 x 10(9) and 1.83 x 10(8) particles, respectively) into the ileal lumen of adult rats. The content of rhodamine in the mesenteric vein and ileal lumen was analysed periodically from 10 min to 48 h as well as the distribution of microspheres in the intestinal mucosa and various other tissues. The concentration of rhodamine decreased progressively in the intestinal lumen and was negligible after 24 h. The number of microspheres in the mesenteric vein increased rapidly and reached a maximum after 4 h whatever the size of the particles. It then decreased progressively, but more rapidly with microspheres > 5 microns than with microspheres < 5 microns. The absorption efficiency was low for the former batch (about 0.11% of the administered dose) and higher for the latter (about 12.7%). The intraileal administration of free rhodamine B was followed by intense labelling of the epithelial cells and basement membranes in mesenteric lymph nodes, spleen, kidney and liver. PLAGA microspheres mainly crossed the intestinal mucosa at the site of Peyer's patches where microspheres of < 5 microns appeared after 3 h. Microspheres > 5 microns were retained in the ileal lumen. A few small microspheres were occasionally observed in the epithelial cells. Only the smallest particles were recovered in the liver, lymph nodes and spleen while basement membranes were always labelled. It is concluded that PLAGA microspheres could be useful for the oral delivery of antigens if their size is between 1 and 5 microns.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-1054950, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-13746138, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-1628895, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-1983142, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-2017198, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-2184739, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-2235881, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-2568449, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-2576440, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-2610110, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-2661061, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-2781856, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-2833966, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-446779, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-5696242, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-620722, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-6300397, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-731637, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-7420474, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-7655821, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-7729286, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-8094929, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-8418185, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-8438613, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-8438614, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-8472299, http://linkedlifedata.com/resource/pubmed/commentcorrection/8982822-8493576
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-8782
pubmed:author
pubmed:issnType
Print
pubmed:volume
189 ( Pt 3)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
491-501
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:8982822-Animals, pubmed-meshheading:8982822-Basement Membrane, pubmed-meshheading:8982822-Biological Transport, pubmed-meshheading:8982822-Fluorescent Dyes, pubmed-meshheading:8982822-Ileum, pubmed-meshheading:8982822-Intestinal Absorption, pubmed-meshheading:8982822-Intestinal Mucosa, pubmed-meshheading:8982822-Kidney, pubmed-meshheading:8982822-Lactic Acid, pubmed-meshheading:8982822-Liver, pubmed-meshheading:8982822-Lymph Nodes, pubmed-meshheading:8982822-Male, pubmed-meshheading:8982822-Mesenteric Veins, pubmed-meshheading:8982822-Microspheres, pubmed-meshheading:8982822-Peyer's Patches, pubmed-meshheading:8982822-Polyglycolic Acid, pubmed-meshheading:8982822-Polymers, pubmed-meshheading:8982822-Rats, pubmed-meshheading:8982822-Rats, Wistar, pubmed-meshheading:8982822-Rhodamines, pubmed-meshheading:8982822-Spleen, pubmed-meshheading:8982822-Time Factors
pubmed:year
1996
pubmed:articleTitle
Intestinal absorption of PLAGA microspheres in the rat.
pubmed:affiliation
CEED Hôpitaux Universitaires, Strasbourg, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't