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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1997-1-22
|
| pubmed:abstractText |
A series of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4] thiadiazole derivatives was prepared and tested to evaluate their antimycotic and antibacterial activities. Anti-HIV-1 activity has also been investigated. Among the test compounds, derivatives 10a-14a and 16c showed anti-HIV-1 activity at concentrations slightly below those cytotoxic. Substitutions at 3 and 6 positions seems to be important in lowering the cytotoxicity of compounds.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0014-827X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
659-64
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8981756-Anti-Bacterial Agents,
pubmed-meshheading:8981756-Anti-HIV Agents,
pubmed-meshheading:8981756-Anti-Infective Agents,
pubmed-meshheading:8981756-Cell Line,
pubmed-meshheading:8981756-HIV-1,
pubmed-meshheading:8981756-Humans,
pubmed-meshheading:8981756-Molecular Structure,
pubmed-meshheading:8981756-Salmonella,
pubmed-meshheading:8981756-Shigella,
pubmed-meshheading:8981756-Staphylococcus aureus,
pubmed-meshheading:8981756-Streptococcus,
pubmed-meshheading:8981756-Thiadiazoles
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles: synthesis, antimicrobial and antiviral activity. II.
|
| pubmed:affiliation |
Istituto Farmacochimico dell'Università di Palermo, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|