Linked Life Data

8977441

Source:http://linkedlifedata.com/resource/pubmed/id/8977441

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-1-23
pubmed:abstractText
One of the most important, robust and evolutionarily conserved functions for neural estrogen receptor (ER) is as a mediator of female sexual behavior. Using homozygotic ER knockout (ERKO) mice we tested the hypothesis that ER controls female receptivity. Females with either two normal copies of the ER gene (wild-types), or an insertational disruption (knockouts) of the ER were ovariectomized. Each female was treated with 17 beta-estradiol (EB) alone, and with EB in combination with progesterone, prior to tests for behavioral receptivity. Under both hormonal conditions female ERKO mice did not display sexual receptivity whereas wild-type litter-mates were receptive to males. Male behavior indicated that females of both genotypes were equally attractive. Brain tissues were examined with immunocytochemical methods showed that ERKOs had greatly reduced levels of ER immunoreactivity in hypothalamus. In sum, the data show that ER is required for the display of sexual receptivity, but is not essential for female attractivity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
138
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
507-10
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Estrogen receptors are essential for female sexual receptivity.
pubmed:affiliation
Department of Biology, University of Virginia, Charlottesville 22903, USA. efr2f@virginia.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.