Linked Life Data

8975910

Source:http://linkedlifedata.com/resource/pubmed/id/8975910

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-2-3
pubmed:databankReference
pubmed:abstractText
The objective of this study was to identify disease-related changes in lymphocyte populations within ileal mucosae of calves with cryptosporidiosis. Groups of five neonatal calves were orally infected at 3 days of age with 10(8) oocysts and maintained in enteric-pathogen-free conditions until clinical disease was established or until the animals had recovered from disease. Age-matched uninfected calves were used for comparison. Ileal mucosal lymphocytes were collected, quantitated, and phenotyped to determine whether changes in lymphocyte composition occurred in infected animals. We observed significantly larger numbers of intraepithelial CD8+ T lymphocytes in ileal mucosae from acutely infected calves compared with those from control animals. In addition, a proportion of intraepithelial CD4+ T cells from acutely infected calves coexpressed CD25, whereas there was an absence of coexpressed CD25 on CD4+ T cells from control calves. Ex vivo reverse transcriptase PCR of RNA from intraepithelial lymphocytes from control calves showed a cytokine expression pattern consisting of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), while intraepithelial lymphocytes from calves with cryptosporidiosis expressed IFN-gamma but not TNF-alpha. Together, the results indicate that changes occur in the ileal intraepithelial lymphocyte population coincidently with Cryptosporidium parvum-induced enteric disease.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-1380032, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-1592435, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-1601309, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-1677668, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-1818225, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-1832321, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-1902342, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-1997419, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-1997443, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-2108092, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-2193057, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-2451518, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-2461518, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-2509325, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-2716783, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-2909180, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-2967580, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-3086437, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-3105867, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-3289331, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-3540573, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-3910626, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-4062089, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-6343828, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-7578982, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-7905464, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-7907581, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-7927745, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-7963532, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-7966870, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-8112615, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-8160359, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-8260599, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-8305131, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-8310658, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-8310661, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-8383717, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-8393846, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-8450217, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-8507401, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-8548847, http://linkedlifedata.com/resource/pubmed/commentcorrection/8975910-8807779
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-90
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Activation of intestinal intraepithelial T lymphocytes in calves infected with Cryptosporidium parvum.
pubmed:affiliation
Department of Veterinary Microbiology and Pathology, Washington State University College of Veterinary Medicine, Pullman 99164, USA. rwyatt@vetmed.wsu.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.