Linked Life Data

8971788

Source:http://linkedlifedata.com/resource/pubmed/id/8971788

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-3-20
pubmed:abstractText
The recent identification of advanced glycation end products (AGEs) of the Maillard reaction in the central nervous system suggests their potential involvement in the aging process. Other studies have also suggested a possible link between AGEs and Alzheimer's disease. To investigate the role of AGEs in Pick's disease, another neurodegenerative disease associated with dementia, we examined the AGE-immunoreaction in Pick's bodies and ballooned neurons, two characteristic neuropathological features of Pick's disease, using antibodies against identified AGE-structures, N epsilon-(carboxymethyl)lysine and pentosidine. These two structures were observed immunohistochemically in Pick's bodies and ballooned neurons of brain tissues obtained at autopsy from three elderly patients diagnosed with Pick's disease. These immunoreactions were further confirmed by absorption experiments and double-immunostaining. The present findings suggest that AGEs are involved in the pathology of Pick's disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
219
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Identification of advanced glycation end products of the Maillard reaction in Pick's disease.
pubmed:affiliation
Department of Neuropsychiatry, Kumamoto University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't